The Frequency of Rotavirus Gastroenteritis in Children from West of Iran and Genotyping of Rotavirus Isolates: A Suggestion for Further Changes in Childhood Immunization Program.

IF 1.4 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Journal of research in health sciences Pub Date : 2024-08-01 Epub Date: 2024-07-31 DOI:10.34172/jrhs.2024.156
Parinaz Sedighi, Manoochehr Karami, Mehta Razzaghi, Maryam Emamjamaat, Abdollah Karimi, Roxana Mansour Ghanaiee, Masoud Alebouyeh, Iraj Sedighi
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引用次数: 0

Abstract

Background: Rotavirus is the most common cause of gastroenteritis among children. Currently, four oral live-attenuated vaccines are available to prevent rotavirus infection. The World Health Organization (WHO) has recommended including rotavirus vaccination in national immunization programs; however, it has not been introduced to the Iranian national immunization program. The study aimed to assess the frequency of rotavirus gastroenteritis in the west of Iran and investigate the necessity of rotavirus vaccination. Study Design: A case series study.

Methods: In this case series study, 284 cases under six years of age who presented with acute gastroenteritis from March 2021 to 2022 to a referral hospital in the west of Iran were evaluated. Data on baseline characteristics, clinical manifestations, results of stool test, ELISA for rotavirus detection, and polymerase chain reaction (PCR) test for genotyping of rotavirus-positive samples were recorded.

Results: Results showed that the prevalence of rotavirus infection was 36.6%. The highest frequency was observed among children aged 6-12 months and during the autumn. According to the PCR results, G1P[8], G9P[8], G9P[4], and G1P [4] were the dominant genotypes, and 33.75% of samples were infected with multiple rotavirus genotypes.

Conclusion: The study highlights the considerable prevalence of rotavirus infection among cases of acute gastroenteritis in children under six years of age who were referred to a referral hospital in the west of Iran and the high diversity of rotavirus genotypes in the targeted community. Consequently, physicians and health policymakers should prioritize strategies for the prevention and control of this infection, particularly by considering the rotavirus vaccine as a priority for the Iranian national immunization program.

伊朗西部儿童患轮状病毒肠胃炎的频率和轮状病毒分离株的基因分型:建议进一步修改儿童免疫计划。
背景:轮状病毒是儿童肠胃炎最常见的病因。目前,有四种口服减毒活疫苗可用于预防轮状病毒感染。世界卫生组织(WHO)建议将轮状病毒疫苗接种纳入国家免疫计划,但伊朗尚未将其纳入国家免疫计划。本研究旨在评估伊朗西部地区轮状病毒肠胃炎的发病率,并调查接种轮状病毒疫苗的必要性。研究设计:病例系列研究:病例系列研究:在这项病例系列研究中,对 2021 年 3 月至 2022 年期间在伊朗西部一家转诊医院就诊的 284 例六岁以下急性肠胃炎病例进行了评估。研究记录了基线特征、临床表现、粪便检测结果、检测轮状病毒的酶联免疫吸附试验(ELISA)和对轮状病毒阳性样本进行基因分型的聚合酶链反应(PCR)试验等数据:结果显示,轮状病毒感染率为 36.6%。结果显示,轮状病毒感染率为 36.6%,6-12 个月的儿童和秋季的儿童感染率最高。PCR结果显示,G1P[8]、G9P[8]、G9P[4]和G1P[4]为主要基因型,33.75%的样本感染多种轮状病毒基因型:这项研究表明,在伊朗西部一家转诊医院就诊的六岁以下儿童急性肠胃炎病例中,轮状病毒感染的发病率相当高,而且目标社区的轮状病毒基因型具有高度多样性。因此,医生和卫生政策制定者应优先考虑预防和控制这种感染的策略,特别是考虑将轮状病毒疫苗作为伊朗国家免疫计划的优先事项。
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来源期刊
Journal of research in health sciences
Journal of research in health sciences PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
2.30
自引率
13.30%
发文量
7
期刊介绍: The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health
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