Age and gender in drug resistance tuberculosis: A cross-sectional case study at a national tuberculosis reference hospital in Nigeria

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES
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Abstract

Objectives

Drug resistance in tuberculosis (TB) is a very important public health threat that should not be ignored. Understanding the gender, age, and characteristics of individuals affected by TB (without HIV, diabetes, or hepatitis B complications), particularly in terms of drug resistance or susceptibility, is crucial for effective prevention and management strategies, as most studies focus on TB/HIV co-infection.

Methods

A cross-sectional case study of age and gender was carried out in 140 individuals grouped into drug-resistant tuberculosis (DR-TB), drug-susceptible tuberculosis (DS-TB), and apparently healthy controls (AHCs). Data collection was through medical records and a structured questionnaire. Statistical analyses compared age, gender, and selected risk factors across the groups.

Results

The mean age of the DR-TB group was 32 years (SD ≈ 2). A total of 80.0% were ≤40 years of age and four times more likely to have DR-TB; 55% were male, with 1.22 times more likelihood of DR-TB in males. The mean age of the DS-TB group was 34 years (SD ≈ 12); 66.7% were ≤40 years old. The odds ratio of DS-TB in males was 2.16. Only 10% of DR-TB enrolees had BCG scars compared with 65% AHCs. A high percentage of the DR-TB group reported handling raw meat (75%) and drinking unpasteurised milk (70%) compared with the DS-TB group.

Conclusions

The observed gender disparities and age-related factors, particularly among the DR-TB group, highlight the importance of considering age and gender factors in DR-TB prevention, diagnosis, and treatment. Our findings also highlight the need to bridge gaps in awareness as well as for the prevention of zoonotic TB and issues around effective BCG vaccination and coverage.
耐药性结核病中的年龄与性别:尼日利亚一家国家结核病参考医院的横断面个案研究。
目的:结核病(TB)的耐药性是一个非常重要的公共卫生威胁,不容忽视。了解结核病患者(无 HIV、糖尿病或乙肝并发症)的性别、年龄和特征,尤其是耐药性或敏感性,对于有效的预防和管理策略至关重要,因为大多数研究都侧重于结核病/HIV 合并感染:方法:对 140 名患者的年龄和性别进行横断面病例研究,分为耐药(DR-TB)、易药(DS-TB)和表面健康对照组(AHC)。数据收集通过医疗记录和结构化问卷进行。统计分析比较了各组的年龄、性别和选定的风险因素:DR-TB 组的平均年龄为 32 岁(SD≈ 2)。80.0%的人年龄小于 40 岁,患 DR-TB 的可能性是正常人的四倍。55%的患者为男性,男性患 DR-TB 的几率是其他男性的 1.22 倍。DS-TB 组的平均年龄为 34 岁(SD ≈ 12)。66.7%的患者年龄小于 40 岁。男性 DS-TB 患病率为 2.16。与 65% 的 AHCs 相比,只有 10% 的 DR-TB 患者有卡介苗疤痕。与 DS-TB 相比,DR-TB 报告处理生肉(75%)和饮用未消毒牛奶(70%)的比例较高:观察到的性别差异和年龄相关因素(尤其是在 DR-TB 中)凸显了在 DR-TB 的预防、诊断和治疗工作中考虑年龄和性别因素的重要性。研究结果还凸显了弥合人畜共患病结核病认识和预防方面的差距以及有效卡介苗接种和覆盖率问题的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of global antimicrobial resistance
Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
8.70
自引率
2.20%
发文量
285
审稿时长
34 weeks
期刊介绍: The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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