Association between changes in high-density lipoprotein cholesterol and risk of cardiovascular disease.

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Ya Wang, Tao Yan, Yuxin Yang, Lehui Li, Ziying Zhang, Xiaodong Cao, Yuan Xia, Yuan Shen, Kun Liu, Lei Xu, Chunfa Zhang, Xingguang Zhang, Nan Zhang
{"title":"Association between changes in high-density lipoprotein cholesterol and risk of cardiovascular disease.","authors":"Ya Wang, Tao Yan, Yuxin Yang, Lehui Li, Ziying Zhang, Xiaodong Cao, Yuan Xia, Yuan Shen, Kun Liu, Lei Xu, Chunfa Zhang, Xingguang Zhang, Nan Zhang","doi":"10.1016/j.jacl.2024.09.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The present study was performed to determine the association between changes in the HDL-C concentration and incident CVD.</p><p><strong>Methods: </strong>Time-dependent Cox regression models were used to evaluate the association between changes in the HDL-C concentration and the risk of incident CVD. Participants were followed up from 2015 to 2021.</p><p><strong>Results: </strong>In total, 24,123 participants with a median follow-up of 4.26 years were analyzed, and the mean age of the cohort was 56.24 years, 57.8 % were female, 24.3 % were current smokers, and 12.8 % had a history of alcohol use. Low, normal, and high HDL-C was defined as <40, 40-80, and >80 mg/dL, respectively. The average time for the two HDL-C measurements was 2.8 years,compared with participants whose HDL-C was maintained at a normal level, the risk of CVD was higher in those whose HDL-C changed to a low level, remained unchanged at a low level(HR, 1.24; 95 % CI, 1.01-1.40,P < 0.001), similarly, the risk of CVD was higher in those whose HDL-C changed from very high level to normal level(HR, 0.81; 95 % CI, 0.67-0.99,P = 0.039). Also compared with participants whose HDL-C was maintained at a normal level, the risk of CVD was lower in those whose HDL-C increased from low to normal and high(HR, 0.80; 95 % CI, 0.66-0.98,P = 0.029).</p><p><strong>Conclusions: </strong>Participants whose HDL-C changed to a low level and whose low HDL-C level was maintained had a higher risk of CVD, whereas participants whose HDL-C changed from low to high had a lower risk of CVD.</p>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical lipidology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jacl.2024.09.001","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The present study was performed to determine the association between changes in the HDL-C concentration and incident CVD.

Methods: Time-dependent Cox regression models were used to evaluate the association between changes in the HDL-C concentration and the risk of incident CVD. Participants were followed up from 2015 to 2021.

Results: In total, 24,123 participants with a median follow-up of 4.26 years were analyzed, and the mean age of the cohort was 56.24 years, 57.8 % were female, 24.3 % were current smokers, and 12.8 % had a history of alcohol use. Low, normal, and high HDL-C was defined as <40, 40-80, and >80 mg/dL, respectively. The average time for the two HDL-C measurements was 2.8 years,compared with participants whose HDL-C was maintained at a normal level, the risk of CVD was higher in those whose HDL-C changed to a low level, remained unchanged at a low level(HR, 1.24; 95 % CI, 1.01-1.40,P < 0.001), similarly, the risk of CVD was higher in those whose HDL-C changed from very high level to normal level(HR, 0.81; 95 % CI, 0.67-0.99,P = 0.039). Also compared with participants whose HDL-C was maintained at a normal level, the risk of CVD was lower in those whose HDL-C increased from low to normal and high(HR, 0.80; 95 % CI, 0.66-0.98,P = 0.029).

Conclusions: Participants whose HDL-C changed to a low level and whose low HDL-C level was maintained had a higher risk of CVD, whereas participants whose HDL-C changed from low to high had a lower risk of CVD.

高密度脂蛋白胆固醇的变化与心血管疾病风险之间的关系。
研究背景本研究旨在确定高密度脂蛋白胆固醇(HDL-C)浓度变化与心血管疾病发病之间的关系:方法:采用时间依赖性 Cox 回归模型评估高密度脂蛋白胆固醇浓度变化与心血管疾病发病风险之间的关系。从 2015 年到 2021 年对参与者进行了随访:共分析了24123名参与者,中位随访时间为4.26年,队列的平均年龄为56.24岁,57.8%为女性,24.3%为当前吸烟者,12.8%有饮酒史。低、正常和高 HDL-C 分别定义为 80 毫克/分升。两次测量 HDL-C 的平均时间为 2.8 年,与 HDL-C 保持正常水平的参与者相比,HDL-C 变为低水平或保持低水平不变的参与者患心血管疾病的风险更高(HR, 1.24; 95 % CI, 1.01-1.40,P < 0.001),同样,HDL-C 从极高水平变为正常水平的参与者患心血管疾病的风险更高(HR, 0.81; 95 % CI, 0.67-0.99,P = 0.039)。此外,与高密度脂蛋白胆固醇维持在正常水平的参与者相比,高密度脂蛋白胆固醇从低水平升至正常和高水平的参与者患心血管疾病的风险较低(HR,0.80;95 % CI,0.66-0.98,P = 0.029):结论:HDL-C变为低水平且低HDL-C水平保持不变的参与者患心血管疾病的风险较高,而HDL-C从低变为高的参与者患心血管疾病的风险较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
7.00
自引率
6.80%
发文量
209
审稿时长
49 days
期刊介绍: Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信