Uncovering the coronavirus outbreak: present understanding and future research paths.

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2024-09-18 eCollection Date: 2024-07-01 DOI:10.1515/jbcpp-2024-0134

Jayati Roy, Arnab Banerjee, Sandip Mukherjee, Bithin K Maji

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引用次数: 0

Abstract

Introduction: The review discusses the pathophysiological mechanisms of SARS-CoV-2, the modes of transmission, and the long-term health consequences of COVID-19, emphasizing the importance of research and successful public health initiatives.

Content: COVID-19 taxonomy, pathophysiology, symptomatology, and epidemiological importance are the key objects of this research paper. This review explains how COVID-19 affects different systems of the body, including respiratory, cardiovascular, and reproductive systems of the human body. It describes the modes of entry of the virus into the cell; more precisely, ACE2 and TMPRSS2 in viral entry. In addition, the present study analyzes the situation of COVID-19 in India regarding vaccine development and the transmission rate related to socioeconomic factors.

Summary: The manifestation of COVID-19 presents a lot of symptoms and post-acute problems, issues which are seriously impacting mental health and physical health as well. The present review summarizes current research into pathogenicity and the mode of virus transmission, together with immunological responses. Coupled with strong vaccination programs, public health initiatives should hold the key to fighting this pandemic.

Outlook: Long-term effects and the development of treatment methods will need further study, as ambiguities on COVID-19 remain. Multidisciplinary collaboration across healthcare sectors in this respect is of paramount importance for the prevention of further spread and protection of public health.

查看原文本刊更多论文

揭开冠状病毒爆发的真相：目前的认识和未来的研究方向。

导言：综述讨论了 SARS-CoV-2 的病理生理机制、传播方式以及 COVID-19 对健康造成的长期影响，强调了研究和成功的公共卫生举措的重要性：COVID-19的分类、病理生理学、症状学和流行病学的重要性是本文研究的主要对象。这篇综述解释了 COVID-19 如何影响人体的不同系统，包括呼吸系统、心血管系统和生殖系统。它描述了病毒进入细胞的方式；更确切地说，是 ACE2 和 TMPRSS2 在病毒进入细胞中的作用。此外，本研究还分析了印度 COVID-19 在疫苗开发方面的情况，以及与社会经济因素相关的传播率。摘要：COVID-19 的表现会带来很多症状和后遗症，严重影响心理健康和身体健康。本综述总结了目前对致病性、病毒传播模式以及免疫反应的研究。展望未来，公共卫生举措加上强有力的疫苗接种计划应是抗击这一流行病的关键所在：展望：由于 COVID-19 仍然存在不确定性，因此长期影响和治疗方法的开发还需要进一步研究。医疗保健部门在这方面的多学科合作对于防止进一步传播和保护公众健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.