The role of probiotics on microvascular complications of type-2 diabetes: Nephropathy and retinopathy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-06-25 DOI:10.34172/jcvtr.32877

Robab Sarmadi, Hajie Lotfi, Mohammad Amin Hejazi, Fariba Ghiasi, Rana Keyhanmanesh

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引用次数: 0

Abstract

Diabetes is a multifactorial disorder that involves several molecular mechanisms and is still one of the key global health challenges with increasing prevalence and incidence. Gut microbiome dysbiosis could activate and recognize receptors that trigger the inflammation response and modulation of insulin sensitivity. In addition, the intricate role of gut microbiota dysbiosis in the onset and development of T2D (Type 2 diabetes mellitus) and associated microvascular complications was identified. These complications include diabetic nephropathy (DN) and diabetic retinopathy (DR), diabetic neuropathy, cerebrovascular disorders, and coronary heart disease. A recent interesting strategy to improve these complications is probiotics administration. The safety and health effects of probiotics against various diseases have been validated by various in vitro, in vivo and clinical studies. In this review, the related mechanisms between the gut microbiome, initiation, and progression of T2D and its common microvascular complications (DN and DR) have been discussed.

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益生菌对 2 型糖尿病微血管并发症的作用：肾病和视网膜病变。

糖尿病是一种涉及多种分子机制的多因素疾病，目前仍是全球健康面临的主要挑战之一，其患病率和发病率都在不断上升。肠道微生物群失调可激活并识别受体，从而引发炎症反应并调节胰岛素敏感性。此外，肠道微生物群失调在 T2D（2 型糖尿病）的发病和发展以及相关微血管并发症中的作用错综复杂。这些并发症包括糖尿病肾病（DN）和糖尿病视网膜病变（DR）、糖尿病神经病变、脑血管疾病和冠心病。最近，一种改善这些并发症的有趣策略是服用益生菌。益生菌对各种疾病的安全性和保健作用已通过各种体外、体内和临床研究得到验证。本综述讨论了肠道微生物群与 T2D 及其常见微血管并发症（DN 和 DR）的发生、发展之间的相关机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.