Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2024-09-20 DOI:10.1177/08853282241268673

Yasin Bayir, Beyzagül Erkayman, Abdulmecit Albayrak, Şaziye Sezin Palabiyik-Yücelik, Sümeyra Can, Hayrunisa Hanci, Fatih Tunç, Hamza Halici, Maide Sena Civelek, Melike Sevim, Emir Enis Yurdgülü, Önder Metin

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引用次数: 0

Abstract

Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H₂O₂ damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.

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用于烧伤治疗的掺杂硼酸和硼酸锌的石墨烯水凝胶：体外活力-生物相容性测试和微生物分析。

硼是人体必需的元素，也是伤口愈合的关键因素。因此，本研究通过体外活力-生物相容性测试和微生物分析，研究了硼产品（硼酸和硼酸锌）和掺杂硼产品的新合成石墨烯水凝胶对烧伤愈合的作用。结果表明，硼酸和硼酸锌对烧伤中常见的微生物有效。在 L929 小鼠成纤维细胞系中，无论是单独使用还是掺杂石墨烯水凝胶，硼酸、硼酸锌和石墨烯水凝胶都没有显示出任何毒性作用，除非剂量非常大。这些物质具有抗氧化特性，能保护细胞免受 H2O2 的损害。对硼产品进行的迁移测试也证实了硼产品的保护作用。本研究首次合成了石墨烯水凝胶，并通过适当的仪器分析完成了其表征。石墨烯水凝胶的生物相容性测试结果表明，其生物相容性至少达到 96%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.