{"title":"Breakfast skipping suppresses vascular endothelial function of the brachial artery after lunch.","authors":"Hideaki Kashima, Natsuki Seo, Masako Yamaoka Endo, Masako Kanda, Kohei Miura, Naomi Kashima, Akira Miura, Yoshiyuki Fukuba","doi":"10.1152/japplphysiol.00681.2023","DOIUrl":null,"url":null,"abstract":"<p><p>Breakfast skipping has been suggested to be associated with cardiovascular diseases. However, whether breakfast skipping affects vascular endothelial function (VEF), a marker of cardiovascular diseases, remains unclear. This study aimed to investigate the impact of breakfast consumption (Eating trial) and skipping (Skipping trial) on brachial artery (BA) VEF in healthy breakfast eaters. A total of nine healthy individuals (four females and five males) either had breakfast between 8:30 and 9:00 or skipped it and had lunch between 12:00 and 12:30, followed by a 3-h rest period until 15:30. For BA VEF evaluation, flow-mediated dilation (FMD) was measured using ultrasound before and after breakfast and lunch. FMD was calculated as the percentage change in BA diameter normalized to the shear rate area under the curve (FMD/SR<sub>AUC</sub>). Blood glucose, plasma insulin, and plasma free fatty acid levels in capillaries were measured before and after breakfast and lunch. At 15:30, the Eating trial, but not the Skipping trial, significantly increased FMD/SR<sub>AUC</sub> from baseline (<i>p</i> = 0.006). The Skipping trial showed significantly lower changes in FMD/SR<sub>AUC</sub> from 8:30 than the Eating trial at 15:30 (<i>p</i> < 0.001). We found a significant inverse correlation between changes in FMD/SR<sub>AUC</sub> between 8:30 and 15:30 and peak glucose levels after lunch (r = -0.882, <i>p</i> < 0.001) and with an incremental area under the curve for glucose between 8:30 and 15:30 (r = -0.668, <i>p</i> < 0.001). These results suggest that a single bout of breakfast skipping can suppress BA VEF in the afternoon due to postlunch hyperglycemia.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00681.2023","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Breakfast skipping has been suggested to be associated with cardiovascular diseases. However, whether breakfast skipping affects vascular endothelial function (VEF), a marker of cardiovascular diseases, remains unclear. This study aimed to investigate the impact of breakfast consumption (Eating trial) and skipping (Skipping trial) on brachial artery (BA) VEF in healthy breakfast eaters. A total of nine healthy individuals (four females and five males) either had breakfast between 8:30 and 9:00 or skipped it and had lunch between 12:00 and 12:30, followed by a 3-h rest period until 15:30. For BA VEF evaluation, flow-mediated dilation (FMD) was measured using ultrasound before and after breakfast and lunch. FMD was calculated as the percentage change in BA diameter normalized to the shear rate area under the curve (FMD/SRAUC). Blood glucose, plasma insulin, and plasma free fatty acid levels in capillaries were measured before and after breakfast and lunch. At 15:30, the Eating trial, but not the Skipping trial, significantly increased FMD/SRAUC from baseline (p = 0.006). The Skipping trial showed significantly lower changes in FMD/SRAUC from 8:30 than the Eating trial at 15:30 (p < 0.001). We found a significant inverse correlation between changes in FMD/SRAUC between 8:30 and 15:30 and peak glucose levels after lunch (r = -0.882, p < 0.001) and with an incremental area under the curve for glucose between 8:30 and 15:30 (r = -0.668, p < 0.001). These results suggest that a single bout of breakfast skipping can suppress BA VEF in the afternoon due to postlunch hyperglycemia.
期刊介绍：
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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