{"title":"Inhibitory effects against zoonotic bacteria by <i>Oroxylum indicum</i> ointment and effects to dog wound.","authors":"Patchima Sithisarn, Piyanuch Rojsanga, Pakatip Ruenraroengsak, Pongtip Sithisarn","doi":"10.4103/JAPTR.JAPTR_97_24","DOIUrl":null,"url":null,"abstract":"<p><p>A topical antimicrobial ointment was developed from the fruit extract of <i>Oroxylum</i> <i>indicum</i> and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. <i>O.</i> <i>indicum</i> fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed <i>in vitro</i> antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of <i>O.</i> <i>indicum</i> and evaluate for its antibacterial and wound-healing effects. <i>O.</i> <i>indicum</i> fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited <i>in</i> <i>vitro</i> antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. <i>O.</i> <i>indicum</i> ointment promoted <i>in vitro</i> antibacterial activity and wound-healing effect in dogs with no acute toxicity.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"15 3","pages":"156-160"},"PeriodicalIF":1.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404433/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Pharmaceutical Technology & Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/JAPTR.JAPTR_97_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
A topical antimicrobial ointment was developed from the fruit extract of Oroxylumindicum and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. O.indicum fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed in vitro antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of O.indicum and evaluate for its antibacterial and wound-healing effects. O.indicum fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited invitro antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. O.indicum ointment promoted in vitro antibacterial activity and wound-healing effect in dogs with no acute toxicity.
期刊介绍:
Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.