Bioadhesive polymer in antifungal drug delivery for therapeutic treatment of candidiasis.

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
Muhamad Naquib Faisal Roslan, Idanawati Naharudin, Nafisah Musa, Nor Khaizan Anuar
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引用次数: 0

Abstract

Candida species are the primary cause of candidiasis, a common yeast infection, with Candida albicans being the most prevalent pathogen. These infections often infiltrate the body through cutaneous and vaginal routes. Given the potential severity of some Candida infections, particularly invasive cases, there is a critical need for effective antifungal treatments. Controlled drug delivery strategies have been developed to achieve optimal release kinetics and precise targeting of active agents, especially in fungal infection therapeutics. Consequently, significant attention has been focused on exploring and utilizing bioadhesive polymers to enhance the performance of drug delivery systems for antifungal medications. Bioadhesive drug delivery systems aim to sustain the release of therapeutic agents, reducing the need for frequent dosing. This article provides a comprehensive review of scientific investigations into the use of antifungal drugs within bioadhesive drug delivery systems for treating candidiasis, locally and systemically. The evaluation covers the efficacy of these systems against candidiasis, factors affecting prolonged contact at the application site, and the underlying mechanisms of drug delivery.

生物粘性聚合物在治疗念珠菌病的抗真菌药物输送中的应用。
念珠菌是念珠菌病(一种常见的酵母菌感染)的主要致病菌,其中白念珠菌是最常见的病原体。这些感染通常通过皮肤和阴道途径渗入人体。鉴于某些念珠菌感染(尤其是侵袭性感染)的潜在严重性,亟需有效的抗真菌治疗方法。为了实现活性药物的最佳释放动力学和精确靶向,特别是在真菌感染治疗方面,人们开发了可控给药策略。因此,探索和利用生物粘附性聚合物来提高抗真菌药物给药系统的性能已成为人们关注的焦点。生物粘附性给药系统旨在持续释放治疗药物,减少频繁给药的需要。本文全面回顾了在生物黏附给药系统中使用抗真菌药物治疗念珠菌病的局部和全身性科学研究。评估内容包括这些系统对念珠菌病的疗效、影响用药部位长时间接触的因素以及药物输送的基本机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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