Ambient air fine particulate matter (PM10 and PM2.5) and risk of type 2 diabetes mellitus and mechanisms of effects: a global systematic review and meta-analysis.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-09-13 DOI:10.1080/09603123.2024.2391993

Salah Azizi, Mohammad Hadi Dehghani, Ramin Nabizadeh

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引用次数: 0

Abstract

Type 2 diabetes causes early mortality worldwide. Air pollution's relationship with T2DM has been studied. The association between them is unclear because of inconsistent outcomes. Studies on this topic have been published since 2019, but not thoroughly evaluated. We conducted a systematic review and meta-analysis using relevant data. The study protocol was registered in PROSPIRO and conducted according to MOOSE guidelines. In total, 4510 manuscripts were found. After screening, 46 studies were assessed using the OHAT tool. This meta-analysis evaluated fine particles with T2DM using OR and HR effect estimates. Evaluation of publication bias was conducted by Egger's test, Begg's test, and funnel plot analysis. A sensitivity analysis was conducted to evaluate the influence of several studies on the total estimations. Results show a significant association between PM2.5 and PM10 exposure and T2DM. Long-term exposure to fine air particles may increase the prevalence and incidence of T2DM. Fine air pollution increases the chance of developing T2DM mainly via systemic inflammation, oxidative stress, and endoplasmic reticulum stress.

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环境空气中的细颗粒物（PM10 和 PM2.5）与 2 型糖尿病的风险及其影响机制：全球系统回顾和荟萃分析。

2 型糖尿病在全球范围内导致早期死亡。空气污染与 2 型糖尿病的关系已被研究。由于结果不一致，二者之间的关系尚不明确。自 2019 年以来，有关这一主题的研究陆续发表，但并未进行全面评估。我们利用相关数据进行了系统回顾和荟萃分析。研究方案已在 PROSPIRO 注册，并根据 MOOSE 指南进行。共找到 4510 篇手稿。经过筛选，使用 OHAT 工具对 46 项研究进行了评估。这项荟萃分析使用 OR 和 HR 效果估计值评估了细颗粒物与 T2DM 的关系。通过 Egger 检验、Begg 检验和漏斗图分析对发表偏倚进行了评估。还进行了敏感性分析，以评估多项研究对总估计值的影响。结果表明，PM2.5 和 PM10 暴露与 T2DM 之间存在明显的关联。长期暴露于细微空气颗粒可能会增加 T2DM 的患病率和发病率。细微空气污染主要通过全身炎症、氧化应激和内质网应激增加 T2DM 的发病几率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.