Incidence of symptomatic Lyme borreliosis in nine European countries

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Frederick J. Angulo , Emily Colby , Anne-Mette Lebech , Per-Eric Lindgren , Anna Moniuszko-Malinowska , Franc Strle , Julia Olsen , Gordon Brestrich , Andrew Vyse , Madiha Shafquat , L. Hannah Gould , Patrick H. Kelly , Andreas Pilz , Kate Halsby , Jennifer C. Moïsi , James H. Stark
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引用次数: 0

Abstract

Objectives

To better understand the Lyme borreliosis (LB) burden in Europe, we aimed to estimate the incidence of symptomatic Borrelia burgdorferi sensu lato (Bbsl) infections after adjusting public health LB surveillance data for under-detection of symptomatic Bbsl infections.

Methods

Data from seroprevalence studies and estimates of the symptomatic proportion and duration of antibody detection in Bbsl-infected individuals, derived from reviews of the published literature, were used to adjust public health LB surveillance data to estimate the incidence of symptomatic Bbsl infection in nine European countries from 2018 to 2022.

Results

The prevalence of anti-Bbsl antibodies ranged from 2.3% in Romania to 9.4% in Germany. Under-detection multipliers varied across surveillance systems; using 10-year duration of antibody detection, multipliers were 2.4-10.5 in countries reporting all LB cases and 54.6-722.2 in countries reporting only Lyme neuroborreliosis cases. The incidence of symptomatic Bbsl infection adjusted for under-detection was highest in Finland, Germany, Norway, Poland, and Switzerland, intermediate in the Czech Republic and Denmark, and lowest in Ireland and Romania.

Conclusion

Adjustment of LB surveillance for under-detection found a high incidence of symptomatic Bbsl infection in several European countries. Differences in LB surveillance systems should be considered when comparing surveillance data between countries and when estimating LB disease burden.
九个欧洲国家无症状莱姆包虫病的发病率。
目的:为了更好地了解莱姆病(Lyme borreliosis,LB)在欧洲造成的负担,我们旨在对公共卫生LB监测数据进行调整,以消除对无症状Bbsl感染的检测不足,从而估计无症状Borrelia burgdorferi sensu lato(Bbsl)感染的发病率:方法:利用血清流行率研究的数据以及对Bbsl感染者中无症状比例和抗体检测持续时间的估计(来自对已发表文献的综述),调整公共卫生LB监测数据,以估计2018-2022年九个欧洲国家无症状Bbsl感染的发病率:抗 Bbsl 抗体的流行率从罗马尼亚的 2.3% 到德国的 9.4% 不等。不同监测系统的检测不足乘数各不相同;使用10年抗体检测持续时间,报告所有枸橼酸病例的国家的乘数为2.4-10.5,仅报告莱姆神经枸橼酸病例的国家的乘数为54.6-722.2。根据检测不足进行调整后,芬兰、德国、挪威、波兰和瑞士的无症状 Bbsl 感染发生率最高,捷克共和国和丹麦居中,爱尔兰和罗马尼亚最低:结论:根据检测不足对结核病监测进行调整后发现,多个欧洲国家的无症状结核病感染率较高。在比较国家间的监测数据和估计结核病负担时,应考虑结核病监测系统的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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