Forty-year single-center experience of Burkholderia cystic fibrosis airway infections

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Burkhard Tümmler , Jutta Ulrich , Ludwig Sedlacek
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引用次数: 0

Abstract

Objectives

To resolve the epidemiology of airway infections with Burkholderia cepacia complex (Bcc) in patients with cystic fibrosis (pwCFs) over 40 years at a single treatment center.

Methods

All Bcc and Burkholderia gladioli airway isolates were collected from pwCFs who presented at the cystic fibrosis outpatient and the lung transplantation clinics from 1983 to 2022.

Results

The collection of 1205 strains is dominated by B. multivorans (56%), followed by B. cenocepacia (16%), B. stabilis (10%), and B. orbicola (9%). A total of 27 pwCFs experienced a single self-limiting episode of airway infection with Bcc. A total of 13 pwCFs were harboring Bcc for 1.7-13.6 years and 15 pwCFs were persistently infected with Bcc. A total of 16 Bcc-positive pwCFs received a lung transplant. Fatal post-transplant sepsis happened in one patient with B. multivorans, two with B. cenocepacia, and two with B. orbicola.

Conclusions

After the first acquisition of Bcc, transient carriage was 2.7 times more frequent than persistent colonization. Infections with B. cenocepacia or B. orbicola confer a higher risk for post-transplant sepsis than an infection with B. multivorans.
伯克霍尔德氏囊性纤维化气道感染的 40 年单一中心经验。
目的分析囊性纤维化患者(pwCF)40年来在单一治疗中心感染伯克霍尔德氏菌复合体(Bcc)气道感染的流行病学:方法:从1983年到2022年,从囊性纤维化门诊和肺移植诊所就诊的囊性纤维化患者中收集了所有Bcc和布克氏菌gladioli气道分离株:结果:在收集到的1205株菌株中,主要是多杀性伯克霍尔德氏菌(56%),其次是卡氏伯克霍尔德氏菌(16%)、稳定伯克霍尔德氏菌(10%)和奥比科拉伯克霍尔德氏菌(9%)。有 27 名儿童患过一次自限性气道感染 Bcc。13名儿童肺结核患者携带Bcc长达1.7至13.6年,15名儿童肺结核患者持续感染Bcc。16名Bcc阳性的CF患者接受了肺移植。1名多杀性巴氏杆菌、2名塞诺巴氏杆菌和2名眶内巴氏杆菌阳性患者在移植后发生了致命的败血症:结论:在首次感染 Bcc 后,短暂携带的频率是持续定植的 2.7 倍。与多杀性巴氏杆菌感染相比,感染塞诺巴氏杆菌或奥比科拉氏杆菌引发移植后败血症的风险更高。
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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