Correlation and Clinical Significance of HBD-2 and CXCL-1/2 Levels at Skin Lesions with Psoriasis Vulgaris Severity.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.1080/08820139.2024.2395852

Ling Lin, Quan Luo, Xinjing Gao, Qian Li, Wei Li, Xin Zhou, Weiyu Liu, Xuelian Zhong, Yunqing Yang, Xibao Zhang

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引用次数: 0

Abstract

Objective: This study was performed to explore the clinical significance of the expression of human beta-defensin 2 (HBD-2) and chemokine ligand 1/2 (CXCL-1/2) in psoriasis vulgaris.

Methods: This study retrospectively included the study group (n = 160) and control group (n = 100) for analysis. The levels of inflammatory indicators, blood biochemical indicators, and immune indicators using ELISA. The psoriasis area and severity index (PASI) was used to evaluate disease severity. Levels of HBD-2, CXCL-1, CXCL-2 and CCL20 were determined by RT-PCR. The correlations of HBD-2, CXCL-1 and CXCL-2 levels with CCL20 and PASI scores were analyzed. The diagnostic value of HBD-2, CXCL-1 and CXCL-2 in psoriasis vulgaris was analyzed by ROC curve.

Results: HBD-2, CXCL-1 and CXCL-2 were highly expressed in the lesions of psoriasis vulgaris patients, and were positively correlated with CCL20 and PASI score. HBD-2, CXCL-1 and CXCL-2 alone or in combination had high diagnostic value for psoriasis vulgaris and severe psoriasis, and the combined diagnostic value of the three was higher than that of a single indicator.

Conclusion: HBD-2, CXCL-1, and CXCL-2 levels are closely related to the severity of psoriasis vulgaris and can effectively diagnose the occurrence and progression of psoriasis vulgaris.

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皮损处 HBD-2 和 CXCL-1/2 水平与银屑病严重程度的相关性和临床意义

研究目的本研究旨在探讨人β防御素2（HBD-2）和趋化因子配体1/2（CXCL-1/2）的表达在寻常型银屑病中的临床意义：本研究回顾性纳入研究组（n = 160）和对照组（n = 100）进行分析。采用 ELISA 方法检测炎症指标、血液生化指标和免疫指标的水平。银屑病面积和严重程度指数（PASI）用于评估疾病的严重程度。通过 RT-PCR 检测 HBD-2、CXCL-1、CXCL-2 和 CCL20 的水平。分析了 HBD-2、CXCL-1 和 CXCL-2 水平与 CCL20 和 PASI 评分的相关性。通过 ROC 曲线分析了 HBD-2、CXCL-1 和 CXCL-2 对寻常型银屑病的诊断价值：结果：HBD-2、CXCL-1和CXCL-2在寻常型银屑病患者皮损中高表达，且与CCL20和PASI评分呈正相关。HBD-2、CXCL-1和CXCL-2单独或联合使用对寻常型银屑病和重症银屑病有较高的诊断价值，三者的联合诊断价值高于单一指标：结论：HBD-2、CXCL-1和CXCL-2水平与寻常型银屑病的严重程度密切相关，可有效诊断寻常型银屑病的发生和发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.