Validation of novel risk prediction models in patients with Brugada syndrome: A multicenter study in Japan.

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-15 DOI:10.1016/j.hrthm.2024.09.024

Tsukasa Kamakura, Masahiko Takagi, Yuki Komatsu, Tetsuji Shinohara, Yoshiyasu Aizawa, Yukio Sekiguchi, Yasuhiro Yokoyama, Naohiko Aihara, Masayasu Hiraoka, Kazutaka Aonuma

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引用次数: 0

Abstract

Background: Risk stratification in patients with Brugada syndrome (BrS) is challenging, especially in those at intermediate risk. The Predicting Arrhythmic evenT (PAT) score has recently been demonstrated to be excellent for predicting future arrhythmic events in patients without prior ventricular fibrillation (VF). However, validation studies are lacking.

Objective: This study aimed to assess the performance of a novel risk stratification model in predicting future VF events in patients with BrS in a Japanese multicenter cohort.

Methods: The PAT score was calculated for 413 patients with BrS (mean age, 50.9 ± 13.6 years; 395 men) from 59 hospitals in Japan, including 314 patients without prior VF. The incidence of developing VF during the follow-up period was investigated.

Results: During the 106.8-month follow-up period, 54 patients (13.1%) experienced VF events. Of the 314 patients without prior VF at enrollment, 14 (4.5%) experienced VF events. The incidence of VF events during the follow-up period was significantly higher in patients with PAT scores ≥ 10 than in those with scores < 10 (41/173 [23.7%] vs 13/240 [5.4%]; P < .0001) in the total cohort. No difference was observed in the incidence of VF events between patients with PAT scores ≥ 10 and < 10 among the 314 patients without prior VF (6/86 [7.0%] vs 8/228 [3.5%]; P = .22). PAT scores ≥ 10 predicted future VF events with a sensitivity and specificity of 42.9% and 73.3%, respectively.

Conclusion: This Japanese multicenter registry demonstrated that the novel risk stratification model could not accurately predict future VF events in patients with BrS but without prior VF.

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新型 Brugada 综合征患者风险预测模型的验证：日本多中心研究

背景：对 Brugada 综合征（BrS）患者进行风险分层具有挑战性，尤其是中危患者。最近的研究表明，预测心律失常评分（PAT）能很好地预测未发生过室颤（VF）的患者未来的心律失常事件。然而，目前还缺乏验证研究：本研究旨在评估一种新型风险分层模型在日本多中心队列中预测 BrS 患者未来 VF 事件的性能：方法：计算了日本 59 家医院的 413 名 BrS 患者（平均年龄为 50.9±13.6 岁，男性 395 人）的 PAT 评分，其中包括 314 名既往未患过室颤的患者。对随访期间发生室颤的发生率进行了调查：结果：在 106.8 个月的随访期间，54 名患者（13.1%）发生了室颤。在 314 名入院时未出现室颤的患者中，有 14 名（4.5%）患者出现了室颤。在随访期间，PAT评分≥10分的患者发生室颤事件的几率明显高于评分≥10分的患者结论：这项日本多中心登记研究表明，新型风险分层模型无法准确预测既往无室颤的 BrS 患者未来的室颤事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.