Long-Term Performance of Subcutaneous Implantable Defibrillators in Athletes: A Multicenter, Real-World Analysis of Sport Activities from the iSUSI Registry.

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-20 DOI:10.1016/j.hrthm.2024.09.039

Alessio Gasperetti, Marco Schiavone, Julia Vogler, Paolo Compagnucci, Mikael Laredo, Alexander Breitenstein, Simone Gulletta, Martin Martinek, Lukas Kaiser, Carlo Lavalle, Sean Gaine, Luca Santini, Antonio Dello Russo, Pietro Palmisano, Giovanni Rovaris, Antonio Curnis, Nicoletta Ventrella, Jürgen Kuschyk, Mauro Biffi, Roland Tilz, Luigi Di Biase, Claudio Tondo, Giovanni B Forleo

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引用次数: 0

Abstract

Background: No data regarding subcutaneous-implantable cardioverter defibrillator (S-ICD) technology in patients actively engaging in sports activities are available.

Objective: This study aims to compare S-ICD performance between athletes and nonathletes.

Methods: The primary outcome of the study was the comparison of overall device-related complications between athletes and nonathletes. Appropriate shocks, inappropriate shocks, and individual device-related complications were secondary outcomes.

Results: A total of 1493 patients were extracted from the International Subcutaneous Implantable Cardioverter Defibrillator Registry (iSUSI) registry, of whom 152 (10.2%) were athletes, mostly engaging in dynamic sports (54.2%). Brugada syndrome, myocarditis, and arrhythmogenic right ventricular cardiomyopathy (ARVC) were more common in athletes (11.2% vs 3.3%, P < .001; 19.1% vs 9.0%, P < .001; 8.6% vs 2.8%, P < .001, respectively). During a median follow-up time of 25.5 (12.0-41.2) months, athletes were more likely to experience appropriate shocks (yearly rate: 7.2 [4.9-10.7] % vs 4.3 [3.6-5.1] %, P = .028), occurring more frequently during exercise (3.9% vs 0.6%, P < .001). This finding lost significance when adjusting for confounders (adjusted hazard ratio [aHR] 1.440 [0.909-2.281], P = .120). No differences were found in overall device-related complications (yearly rate: 3.3% vs 3.4%, P = .448) and inappropriate shocks (yearly rate: 5.3% vs 3.7%, P = 0.111). Myopotential oversensing (4.0% vs 1.3%, P = .011) was more common in athletes, as were lead infections (3.3% vs 0.9%, P =.008), with the latter clustering in the early postimplantation period.

Conclusion: The S-ICD is a valid therapeutic option for preventing sudden cardiac death in athletes. Sports practice was not associated with an increased risk of complications or inappropriate shocks, although athletes are exposed to a higher risk of S-ICD infections in the early postoperative period.

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运动员皮下植入式除颤器的长期性能：来自 iSUSI 注册中心的多中心、真实世界体育活动分析。

背景：目前还没有关于皮下智能体外除颤器（S-ICD）技术在积极参与体育活动的患者中应用的数据：目前还没有关于皮下智能体外除颤器（S-ICD）技术在积极参加体育活动的患者中应用的数据：比较运动员和非运动员的 S-ICD 性能：研究的主要结果是比较运动员和非运动员之间与设备相关的总体并发症。适当冲击、不适当冲击和单个设备相关并发症是次要结果：iSUSI登记处共抽取了1493名患者，其中152人（10.2%）为运动员，大部分从事动态运动（54.2%）。Brugada综合征、心肌炎和ARVC在运动员中更为常见（11.2%vs.3.3%，p）：S-ICD是预防运动员心脏性猝死的有效治疗方案。虽然运动员在术后早期感染 S-ICD 的风险较高，但体育锻炼与并发症或不当电击风险的增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.