Increased arterial stiffness in Crohn's disease: Prevalence, associated factors and impact of anti-TNF therapy.

IF 2.2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Mahrez Fissah, Adel Rechach, Meriem Charifi, Farouk Menzou, Said Taharboucht, Messaouda Djouhri, Leila Talbi, Nadia Touati, Lamine Atif, Mehdi Rabhia, Ahcene Chibane
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Abstract

Introduction: Recent studies have demonstrated the growing interest in cardiovascular risk in Crohn's disease (CD), the aim of our work is to highlight the need for research into the frequency of arterial stiffness (AS) and its link with certain associated factors, particularly those related to inflammation.

Materials and methods: This was a cross-sectional observational study involving 118 patients with CD. Pulse wave velocity (PWV) measured by applanation tonometry was the criterion for calculating AS, the study also investigated the association of AS especially the indicators of inflammation, as well as the impact of anti-TNF alpha therapy on AS.

Results: The prevalence of AS, after adjustment for age and blood pressure level reached more than a quarter of patients compared to the cardiovascular risk which was low. The factors that were strongly associated with AS were age, systolic and diastolic blood pressure. Two parameters related to inflammation emerged as having a highly significant link after multivariate analysis: recurrence in the last year and length of disease with a p=0.008, and an OR of 5 and 9 successively. Patients treated with anti-TNF alpha had a significant reduction in PWV.

Conclusion: The prevalence of AS reached more than a quarter of patients with CD, the duration and recurrence rate of CD appear to be factors linked to inflammation. Treatment with anti-TNF alpha seems to slow down PWV in these patients.

克罗恩病患者动脉僵化加剧:发病率、相关因素和抗肿瘤坏死因子疗法的影响。
导言:最近的研究表明,人们越来越关注克罗恩病(CD)的心血管风险,我们的工作旨在强调研究动脉僵化(AS)频率及其与某些相关因素(尤其是与炎症有关的因素)之间联系的必要性:这是一项横断面观察研究,涉及 118 名 CD 患者。研究还调查了动脉僵化与炎症指标的关联,以及抗 TNF α 治疗对动脉僵化的影响:结果:在对年龄和血压水平进行调整后,超过四分之一的患者患有强直性脊柱炎,而心血管风险较低。与强直性脊柱炎密切相关的因素是年龄、收缩压和舒张压。经过多变量分析,有两个与炎症相关的参数与强直性脊柱炎有非常显著的联系:去年的复发率和病程,P=0.008,OR 值分别为 5 和 9。接受抗 TNF α 治疗的患者脉搏波速度明显降低。结论 :在CD患者中,强直性脊柱炎的发病率超过四分之一,CD的病程和复发率似乎与炎症有关。抗肿瘤坏死因子α治疗似乎能减缓这些患者的脉搏波速度。
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来源期刊
Gastroenterologia y hepatologia
Gastroenterologia y hepatologia GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
1.50
自引率
10.50%
发文量
147
审稿时长
48 days
期刊介绍: Gastroenterology and Hepatology is the first journal to cover the latest advances in pathology of the gastrointestinal tract, liver, pancreas, and bile ducts, making it an indispensable tool for gastroenterologists, hepatologists, internists and general practitioners.
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