Prophylactic endoscopic vacuum therapy for stricture prevention after wide-field endoscopic submucosal dissection of superficial esophageal cancer

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2025-03-01 DOI:10.1016/j.gie.2024.08.011

Tobias Blasberg MD , Moritz Meiborg MD , Johannes Richl MD , Marie Weber MD , Lukas Hiebel MD , Ardian Mekolli MD , Ali Seif Amir Hosseini MD , Ahmad Amanzada MD , Volker Ellenrieder MD , Jürgen Hochberger MD , Edris Wedi MD, PhD

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引用次数: 0

Abstract

Background and Aims

Esophageal stricture is a severe adverse event after wide-field endoscopic submucosal dissection (ESD) of superficial esophageal carcinoma. This study evaluated the efficacy and safety of combining endoscopic vacuum therapy (EVT) and a budesonide orodispersible tablet (BOT) in preventing post-ESD strictures.

Methods

This prospective case series included patients with superficial esophageal squamous cell carcinoma and adenocarcinoma who had wide-field ESD (≥75% circumference, resection length ≥50 mm). After ESD, EVT was applied immediately followed by 8 weeks of BOTs. The main outcome measurement was the incidence of post-ESD stricture.

Results

Eleven patients underwent ESD. Of these, 81.8% had 75% to 99% circumference resected and 18.2% had a circumferential resection. EVT remained in situ for a mean of 3.5 days. No esophageal strictures were observed by the final follow-up, and no major adverse events occurred related to EVT or the BOT.

Conclusions

The prophylactic combination of EVT and BOT is a novel and promising strategy for reducing post-ESD strictures.

查看原文本刊更多论文

预防性内窥镜真空疗法用于预防浅表食管癌宽视野内窥镜粘膜下剥离术后的狭窄。

背景和目的：食管狭窄（ES）是浅表食管癌宽视野内镜黏膜下剥离术（ESD）后的一种严重不良反应。本研究评估了内镜下真空治疗（EVT）与布地奈德口崩片剂（BOT）联合使用预防ESD术后狭窄的有效性和安全性：该前瞻性病例系列包括接受宽视野ESD（周长≥75%，切除长度≥50 mm）的浅表食管鳞状细胞癌和腺癌患者。ESD后，立即进行EVT，然后进行为期8周的BOT。主要结果是ESD后狭窄的发生率：结果：11 名患者接受了 ESD。结果：11 名患者接受了 ESD，其中 81.8% 的患者切除了 75-99% 的周径，18.2% 的患者进行了周径切除。EVT留在原位的时间平均为 3.5 天。最终随访时未发现食管狭窄。EVT和BOT均未发生重大不良事件：EVT和BOT的预防性组合是减少ESD术后食管狭窄的一种新颖且有前景的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.