Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.

IF 3.2 4区医学 Q3 CHEMISTRY, MEDICINAL

Future medicinal chemistry Pub Date : 2024-09-23 DOI:10.1080/17568919.2024.2401310

Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg

引用次数: 0

Abstract

Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.

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作为抗疟疾剂的有机碲（IV）复合物：合成、表征和计算见解。

目的：合成并评估新型有机碲（IV）噻吩基复合物的抗疟和抗氧化活性：使用核磁共振、红外和质谱对合成的复合物进行表征。材料与方法：利用核磁共振、红外光谱和质谱对合成的复合物进行了表征，并利用体外试验和分子对接研究对其生物活性进行了评估：结果：复合物对恶性疟原虫具有明显的抗疟活性，其中复合物 5b 和 5e 的活性最高。ADMET 特性证实了它们作为治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future medicinal chemistry CHEMISTRY, MEDICINAL-

CiteScore

5.80

自引率

2.40%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.