Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-09-23 DOI:10.1080/17568919.2024.2401310

Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg

引用次数: 0

Abstract

Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.

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作为抗疟疾剂的有机碲（IV）复合物：合成、表征和计算见解。

目的：合成并评估新型有机碲（IV）噻吩基复合物的抗疟和抗氧化活性：使用核磁共振、红外和质谱对合成的复合物进行表征。材料与方法：利用核磁共振、红外光谱和质谱对合成的复合物进行了表征，并利用体外试验和分子对接研究对其生物活性进行了评估：结果：复合物对恶性疟原虫具有明显的抗疟活性，其中复合物 5b 和 5e 的活性最高。ADMET 特性证实了它们作为治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567