Exploring biological activities of novel Schiff bases derived from amlodipine and in silico molecular modeling studies.

IF 3.2 4区医学 Q3 CHEMISTRY, MEDICINAL

Future medicinal chemistry Pub Date : 2024-09-20 DOI:10.1080/17568919.2024.2401313

Anum Masood, Mohsin Abbas Khan, Mashooq A Bhat, Breena Awan, Ramsha Hanif, Asim Raza, Saharish Khaliq, Javaid Ahmed, Farhat Ullah

引用次数: 0

Abstract

Aim: Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies.Materials & methods: Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques (¹H NMR, FTIR, ¹³C NMR) and docking studies also performed.Results & conclusion: 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.

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探索由氨氯地平衍生的新型希夫碱的生物活性并进行硅学分子建模研究。

材料与方法：制备了氨氯地平的希夫碱衍生物，以检测其脲酶抑制潜力以及抗菌和抗氧化活性。结果与结论：与母药相比，3g 具有显著的抗高血压活性。3b、3f 和 3g 具有抑制脲酶的潜力。由于这些化合物表现出相似或更优越的相互作用，因此可以作为进一步研究的线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future medicinal chemistry CHEMISTRY, MEDICINAL-

CiteScore

5.80

自引率

2.40%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.