Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in bacterial infections: contributions to diagnostic strategies in a tertiary care hospital in Tunisia.

Q2 Pharmacology, Toxicology and Pharmaceutics

F1000Research Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.146952.1

Jihed Anoun, Mariem Ajmi, Salma Riahi, Yosra Dhaha, Donia Mbarki, Imen Ben Hassine, Wiem Romdhane, Wafa Baya, Najah Adaily, Anis Mzabi, Fatma Ben Fredj, Amina Bouattay

{"title":"Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in bacterial infections: contributions to diagnostic strategies in a tertiary care hospital in Tunisia.","authors":"Jihed Anoun, Mariem Ajmi, Salma Riahi, Yosra Dhaha, Donia Mbarki, Imen Ben Hassine, Wiem Romdhane, Wafa Baya, Najah Adaily, Anis Mzabi, Fatma Ben Fredj, Amina Bouattay","doi":"10.12688/f1000research.146952.1","DOIUrl":null,"url":null,"abstract":"Background: Bacterial infections continue to pose a global health challenge, driven by antibiotic resistance and septicemia. This study aimed to assess the diagnostic utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in bacterial infections versus non-infectious causes of inflammation.Methods: A prospective study included 164 adult patients who were divided into two groups: a group of patients with confirmed bacterial infections and a second group of patients with other diagnoses (inflammatory pathologies, neoplasms, venous thromboembolic diseases, etc.). NLR and PLR values were compared between the bacterial infection group and the non-infectious causes group and the diagnostic performances of NLR and PLR for detecting bacterial infections were evaluated in comparison with other infection markers.Results: NLR and PLR were significantly higher in bacterial infections (p < 10 ^-6), and NLR was correlated positively with inflammation markers. NLR and PLR demonstrated significant potential in diagnosing bacterial infections, with an AUC of 0.72 and 0.60, respectively, using the following cutoff values: 4.3 for NLR and 183 for PLR.Conclusion: These findings underscore the importance of NLR and PLR as adjunctive tools for bacterial infection diagnosis.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"978"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408912/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"F1000Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/f1000research.146952.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Bacterial infections continue to pose a global health challenge, driven by antibiotic resistance and septicemia. This study aimed to assess the diagnostic utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in bacterial infections versus non-infectious causes of inflammation.

Methods: A prospective study included 164 adult patients who were divided into two groups: a group of patients with confirmed bacterial infections and a second group of patients with other diagnoses (inflammatory pathologies, neoplasms, venous thromboembolic diseases, etc.). NLR and PLR values were compared between the bacterial infection group and the non-infectious causes group and the diagnostic performances of NLR and PLR for detecting bacterial infections were evaluated in comparison with other infection markers.

Results: NLR and PLR were significantly higher in bacterial infections (p < 10 ^{^-6}), and NLR was correlated positively with inflammation markers. NLR and PLR demonstrated significant potential in diagnosing bacterial infections, with an AUC of 0.72 and 0.60, respectively, using the following cutoff values: 4.3 for NLR and 183 for PLR.

Conclusion: These findings underscore the importance of NLR and PLR as adjunctive tools for bacterial infection diagnosis.

查看原文本刊更多论文

细菌感染中的中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率：突尼斯一家三级医院的诊断策略。

背景：在抗生素耐药性和败血症的驱动下，细菌感染继续对全球健康构成挑战。本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在细菌感染与非感染性炎症病因中的诊断效用：一项前瞻性研究纳入了 164 名成年患者，将其分为两组：一组是确诊为细菌感染的患者，另一组是确诊为其他疾病（炎症性病变、肿瘤、静脉血栓栓塞性疾病等）的患者。比较了细菌感染组和非感染组的 NLR 和 PLR 值，并评估了 NLR 和 PLR 与其他感染标志物相比在检测细菌感染方面的诊断性能：结果：NLR 和 PLR 在细菌感染中明显升高（P < 10 ^-6），NLR 与炎症指标呈正相关。NLR和PLR在诊断细菌感染方面具有明显的潜力，使用以下临界值时，其AUC分别为0.72和0.60：结论：这些发现强调了 NLR 和 PLR 作为细菌感染诊断辅助工具的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

期刊介绍： F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.