A systematic review of recent advances in urinary tract infection interventions and treatment technology.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2024-09-01 DOI:10.26355/eurrev_202409_36713

M S Alam, M J Anwar, M S Akhtar, P Alam, A A S Mohammad, A F Almutairy, A S Nazmi, T K Mukherjee

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引用次数: 0

Abstract

Objective: Urinary tract infection is one of the most common extraintestinal infectious diseases encountered in clinics. It affects both genders and all age groups and constitutes a major health issue in clinical practice worldwide. Uropathogens often develop resistance to therapeutic agents, creating a formidable challenge for physicians to treat these infections. The goal of the current review is to provide current information on therapeutic advancements and interventions in the treatment of urinary tract infections.

Materials and methods: Databases like MEDLINE, PubMed, and ClinicalTrials.gov were used as search engines to collect the relevant articles, and the required information was extracted.

Results: Research data suggest an increasing prevalence of pathogenic strains that are resistant to standard antimicrobial regimens recommended for the treatment of urinary tract infections. Targeted therapies for urinary tract infections, such as mannosides and pilicides, as well as vaccinations against uropathogenic Escherichia coli, have been developed recently. The efficacy of other strategies like iontophoresis, hydrogel-coated catheters, and antibiofilm therapy is also investigated. Clinical trials conducted between 2014 and 2019 show a rise in interest in a variety of therapies, highlighting the need for a thorough strategy to treat urinary tract infections, particularly in populations of women.

Conclusions: Antimicrobial-resistant strains of Escherichia coli are becoming more common in urinary tract infections, which have led to the development of targeted medicines such as mannosides and pilicides, as well as immunizations against the pathogenic Escherichia coli strains. There is continuing research into alternate approaches, such as hydrogel-coated catheters, antibiofilm therapy, and iontophoresis. Clinical trials conducted between 2014 and 2019 showed a rise in interest in these different treatment approaches.

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系统回顾尿路感染干预和治疗技术的最新进展。

目的：尿路感染是临床上最常见的肠道外传染病之一。它影响着男女老少，是全球临床实践中的一个主要健康问题。泌尿道病原体常常对治疗药物产生抗药性，这给医生治疗这些感染带来了巨大挑战。本综述旨在提供治疗尿路感染的最新进展和干预措施：使用 MEDLINE、PubMed 和 ClinicalTrials.gov 等数据库作为搜索引擎收集相关文章，并提取所需信息：研究数据表明，对治疗尿路感染的标准抗菌药物方案产生耐药性的病原菌株越来越多。最近开发出了治疗尿路感染的靶向疗法，如甘露糖苷和皮利酮，以及针对尿路致病性大肠杆菌的疫苗。此外，还在研究离子透入疗法、水凝胶涂层导管和抗生物膜疗法等其他策略的疗效。2014年至2019年期间进行的临床试验显示，人们对各种疗法的兴趣有所上升，这凸显出需要一种彻底的策略来治疗尿路感染，尤其是在女性人群中：尿路感染中大肠埃希菌的抗菌耐药菌株越来越常见，这导致了甘露糖苷和皮利酮等靶向药物的开发，以及针对致病性大肠埃希菌菌株的免疫接种。目前还在继续研究其他方法，如水凝胶涂层导管、抗生物膜疗法和离子透入疗法。2014 年至 2019 年期间进行的临床试验显示，人们对这些不同治疗方法的兴趣有所上升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)