Anna Traninger, Andreas Blesl, Andrea Borenich, Stefan Fürst, Thomas Wagner, Reinhard Bernd Raggam, Andrea Berghold, Christoph Högenauer
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引用次数: 0
Abstract
Background: Factor XIII plays a key role within the coagulation cascade.
Objective: We aimed to investigate the relevance of factor XIII activity on the outcome of patients with gastrointestinal bleedings.
Methods: In this retrospective, single-center study patients with gastrointestinal bleeding and measurement of factor XIII activity were included. The primary endpoint was the number of red blood cell transfusions in patients with reduced factor XIII activity (< 70%) compared to patients with normal activity. Additionally, the influence of factor XIII substitution was assessed.
Results: Ninety-seven patients (median age: 64 [IQR 55, 77] years, 31 (32%) females) were included in the analysis. Fifty-six (58%) patients suffered from an upper gastrointestinal bleeding. 66 (68%) patients had a factor XIII activity < 70% and 24 (36%) of those received factor XIII substitution. Patients with reduced FXIII activity needed significantly more red blood cell transfusions than patients with normal activity (9 [5, 12] vs. 4 [1, 8], p < 0.001). Patients receiving factor XIII substitution showed a trend toward a decreased need for transfusions after substitution (0 [0, 5] vs. 3 [1, 6], p = 0.066). Factor XIII activity correlated negatively with the INR (rs = -0.24, p = 0.018) and positively with hemoglobin levels (rs = 0.28, p = 0.006) and with thrombocyte counts (rs = 0.30, p = 0.003).
Conclusion: The present study shows an association of factor XIII activity with the requirement of blood transfusions in patients with gastrointestinal bleedings and indicates a potential benefit of factor XIII substitution. Factor XIII activity seems to be dependent from the amount of blood loss and the global coagulation parameters.
背景：因子 XIII 在凝血级联中起着关键作用：因子 XIII 在凝血级联中起着关键作用：我们旨在研究因子 XIII 活性与消化道出血患者预后的相关性：在这项回顾性的单中心研究中，纳入了胃肠道出血患者并测量了因子 XIII 活性。主要终点是因子 XIII 活性降低的患者输注红细胞的次数：97名患者（中位年龄：64 [IQR：55，77] 岁，31（32%）名女性）被纳入分析。56（58%）名患者患有上消化道出血。66（68%）名患者的因子 XIII 活性 s = -0.24，p = 0.018）与血红蛋白水平（rs = 0.28，p = 0.006）和血小板计数（rs = 0.30，p = 0.003）呈正相关：本研究显示因子 XIII 活性与消化道出血患者的输血需求有关，并表明因子 XIII 替代品可能带来益处。因子 XIII 活性似乎与失血量和整体凝血参数有关。
期刊介绍：
Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.
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