Nanomedicine in Management of Cerebral Infarction and Brain Cancer: Role of Inflammation.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Vikas Kumar, Fahad Al-Abbasi, Firoz Anwar, Jonathan A Lal
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引用次数: 0

Abstract

Introduction: Cerebral infarction, the blockage of blood vessels in the brain, is generally an age-related illness. Factors such as unhealthy diets, stressful behaviours and decreased environmental consistency with physiological barriers also contribute to increased casualties. Long-term brain function reconstruction and successful drug therapy are needed. The most frequent malignant brain tumour, glioblastoma, has been linked to variations in mitochondrial ROS, chaperone-mediated autophagy, and the interaction between lncRNA (BC200) and miRNA. Glioblastoma stem cells express high levels of ATP/P2X7 receptors, promoting survival by activating M2 muscarinic receptors.

Areas covered: This expert opinion provides an overview of the latest experimental drug therapies aimed at protecting against and restoring cerebral stroke.

Expert opinion: Nanomedicine overcomes the challenges associated with traditional therapy and physiological obstacles in the treatment of cerebral infarction by improving stroke management, including diagnosis, imaging, and treatment, addressing a diverse range of associated factors.

纳米药物治疗脑梗塞和脑癌:炎症的作用
简介脑梗塞(脑血管堵塞)通常是一种与年龄有关的疾病。不健康的饮食、紧张的行为和环境与生理障碍的一致性降低等因素也是导致伤亡人数增加的原因。需要长期的脑功能重建和成功的药物治疗。最常见的恶性脑肿瘤胶质母细胞瘤与线粒体 ROS 的变化、伴侣介导的自噬以及 lncRNA(BC200)和 miRNA 之间的相互作用有关。胶质母细胞瘤干细胞表达高水平的ATP/P2X7受体,通过激活M2毒蕈碱受体促进存活:本专家意见概述了旨在预防和恢复脑中风的最新实验性药物疗法:纳米医学克服了脑梗塞治疗中与传统疗法和生理障碍相关的挑战,改善了脑卒中的管理,包括诊断、成像和治疗,解决了各种相关因素。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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