Maternal and Fetal Outcomes in Disseminated Intravascular Coagulation Cases Associated with Pregnancy Complications.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-09-01 DOI:10.7754/Clin.Lab.2024.231228

Yuksel Oguz, Gulsah Dagdeviren, Münevver Aksoy, Ayşe Keleş, Özge Y Çelik, Kadriye Y Yucel, Ali T Çağlar

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引用次数: 0

Abstract

Background: The relationship between the pregnancy modified DIC score, which is applied in obstetric conditions where the risk of disseminated intravascular coagulation is high, and underlying disease, as well as its effect on the prognosis, was investigated.

Methods: Those with a DIC score ≥ 26 from obstetric conditions, such as obstetric bleeding, placental abruption, or preeclampsia/HELLP syndrome, which are at high risk of developing DIC, were included in the study. These patients were compared in terms of laboratory results, maternal morbidity/mortality, and neonatal outcomes, according to the underlying disease.

Results: The DIC score was ≥ 26 in 224 of 154,233 deliveries in our center, and the incidence was 0.14%. In the preeclampsia/HELLP syndrome group, the platelet count and prothrombin time were lower, and the fibrinogen level was higher than those of the obstetric hemorrhage and placental abruption groups. In addition, the rates of blood transfusion and hysterectomy were lower in women who developed DIC due to pre-eclampsia/HELLP syndrome than in those with obstetric hemorrhage.

Conclusions: Considering the underlying disease is an important factor in predicting prognosis, when using the new pregnancy modified diagnostic scores for DIC diagnosis.

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与妊娠并发症相关的弥散性血管内凝血病例中的母体和胎儿结局。

背景：研究了妊娠改良DIC评分（适用于弥散性血管内凝血风险较高的产科情况）与基础疾病之间的关系及其对预后的影响：研究对象包括产科出血、胎盘早剥、子痫前期/HELLP 综合征等产科疾病导致的 DIC 评分≥26 分的高危产妇。根据基础疾病，对这些患者的实验室结果、孕产妇发病率/死亡率和新生儿结局进行比较：结果：本中心 154 233 例分娩中有 224 例 DIC 评分≥26，发生率为 0.14%。与产科出血组和胎盘早剥组相比，子痫前期/HELLP 综合征组的血小板计数和凝血酶原时间较低，纤维蛋白原水平较高。此外，因先兆子痫/HELLP综合征而发生DIC的妇女输血率和子宫切除率均低于产科出血组：结论：在使用新的妊娠改良诊断评分进行 DIC 诊断时，考虑潜在疾病是预测预后的一个重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.