A Case of Erythrocyte Condensation Caused by Mycoplasma Pneumoniae Infection.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-09-01 DOI:10.7754/Clin.Lab.2024.240415

Tao Lu, Minjie Wu

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引用次数: 0

Abstract

Background: Blood routine testing was the most commonly used laboratory method in clinical practice. The results are often influenced by factors such as instruments, reagents, and samples, among which, the interference of cold agglutinin is a very rare element. In our article, we reported a case of red blood cell agglutination caused by Mycoplasma pneumoniae infection.

Methods: The number of blood cells were detected by blood routine analyzer with or without treatment at 37℃ water bath. The red blood cell agglutination was observed through blood smear staining. The cold agglutination test were performed using O-type red blood cells added into patient's plasma and refrigerated overnight at 4℃. We also used luminescent immunoassay technology to detect the content of MP antibodies in patient's serum.

Results: The patient's results were RBC (2.69 x 1012/L), MCH (48.5 pg), MCHC (522 g/L). Through a microscope, we observed red blood cell agglutination. The concentration of MP-igM was 60.37 AU/mL. The cold agglutination test was positive. Following a 37℃ water bath, the patient's results changed: RBC (3.85 x 1012/L), MCH (31.2 pg), MCHC (352 g/L). The phenomenon of massive agglutination of red blood cells has also disappeared.

Conclusions: The cold agglutinin produced by MP infection can alter the results of red blood cell. During the epidemic period of MP infection, it is important to pay attention to the phenomenon of abnormal elevation of MCHC in clinical practice.

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肺炎支原体感染导致红细胞凝集的一个病例

背景：血常规检测是临床上最常用的实验室方法。其结果往往受到仪器、试剂、样本等因素的影响，其中冷凝集素的干扰是非常罕见的因素。本文报告了一例由肺炎支原体感染引起的红细胞凝集：方法：用血常规分析仪检测在 37℃水浴条件下处理或未处理的血细胞数。通过血涂片染色观察红细胞凝集。冷凝集试验是在患者血浆中加入 O 型红细胞，在 4℃下冷藏过夜后进行的。我们还使用发光免疫测定技术检测了患者血清中 MP 抗体的含量：患者的检测结果为红细胞（2.69 x 1012/L）、MCH（48.5 pg）、MCHC（522 g/L）。通过显微镜，我们观察到红细胞凝集。MP-igM 的浓度为 60.37 AU/mL。冷凝集试验呈阳性。37℃ 水浴后，患者的结果发生了变化：红细胞（3.85 x 1012/L）、MCH（31.2 pg）、MCHC（352 g/L）。红细胞大量凝集的现象也消失了：结论：MP 感染产生的冷凝集素可改变红细胞的结果。结论：MP 感染产生的冷凝集素可改变红细胞结果，在 MP 感染流行期间，临床上应注意 MCHC 的异常升高现象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.