Reference Intervals of Renal Function Set Established for Healthy Pregnant Women.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-09-01 DOI:10.7754/Clin.Lab.2024.240310

Wenjing Wu, Ran Zhang

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Abstract

Background: This cross-sectional study aimed to explore the variation trend of renal function for healthy pregnant women at different gestational ages and aimed to establish RIs for renal function set tests according to the trimester of pregnancy.

Methods: A total of 120 healthy pregnant women and 40 healthy non-pregnant women were enrolled in this study and divided into early trimester (1 - 13 weeks of gestation, n = 40), second trimester (14 - 27 weeks of gestation, n = 40), third trimester (≥ 28 weeks of gestation, n = 40), and a non-pregnant women group (n = 40). Analytes of UA, BUN, Cr, β2-MG, Cys-C, RBP, NAG, CO2, HCY, C1q, and NGAL were measured by using the analytical systems of the Second Xiangya Hospital. The RIs were defined by using non-parametric 95% intervals.

Results: The RIs for UA, Cr, β2-MG, NAG, CO2, Hcy, and C1q were established for the first and second trimester group and the third trimester group. There were huge differences after pregnancy. The RIs for BUN were different for the 1 - 13 weeks group and the after 14 weeks group. There were significant differences for NGAL in pregnant and non-pregnant women, but not for Cys-C and RBP.

Conclusions: The RIs for renal function tests in pregnant women were established, thus providing clinical reference intervals for the clinicians.

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为健康孕妇设定肾功能参考区间。

背景：这项横断面研究旨在探讨健康孕妇在不同孕龄的肾功能变化趋势，并根据孕期三个月建立肾功能设定测试的RI：这项横断面研究旨在探讨健康孕妇在不同孕龄的肾功能变化趋势，并根据妊娠三个月确定肾功能全套检查的RI：本研究共纳入了 120 名健康孕妇和 40 名健康非孕妇，并将其分为孕早期（妊娠 1 - 13 周，n = 40）、孕中期（妊娠 14 - 27 周，n = 40）、孕中期（≥ 28 周，n = 40）和非孕妇组（n = 40）。使用湘雅二医院的分析系统测量 UA、BUN、Cr、β2-MG、Cys-C、RBP、NAG、CO2、HCY、C1q 和 NGAL。RIs采用非参数95%区间定义：结果：妊娠头三个月组、妊娠后三个月组、妊娠前三个月组和妊娠后三个月组的尿酸、铬、β2-MG、NAG、CO2、Hcy和C1q的RIs均已确定。妊娠后存在巨大差异。妊娠 1-13 周组和妊娠 14 周后组的 BUN 相关系数不同。孕妇和非孕妇的 NGAL 有明显差异，但 Cys-C 和 RBP 没有差异：结论：确定了孕妇肾功能检测的参考区间，从而为临床医生提供了临床参考区间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.