The beneficial effect of fermented Spirulina platensis on reducing oxidative stress in patients with type 2 diabetes mellitus.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-08 DOI:10.14715/cmb/2024.70.8.10

Aida Ghafari Ashtiani, Anousheh Sharifan, Morteza Gharibi, Rahmatollah Moradzadeh

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引用次数: 0

Abstract

Oxidative stress caused by hyperglycemia can lead to the intensification of hyperglycemia and an increased risk of diabetes complications. Spirulina platensis is a potent free-radical scavenger; it has the potential to be used as a substrate for fermentation by lactic acid bacteria. This study aimed to formulate two functional foods with antioxidant capacity (yogurt containing S. platensis powder / fermented S. platensis powder) for Type 2 Diabetes Mellitus (T2DM) patients and compare the antioxidant effects in diabetic subjects. In this article, for the first time, the antioxidant effect of fermented and non-fermented Spirulina was compared in a clinical study in 'T2DM' patients. By blood sampling, clinical parameters such as FBS, GSH, FRAP, MDA, and CRP before and after each treatment were measured and results were compared between two groups of intervention. Both products as functional foods have a positive effect on the health of diabetic patients by reducing FBS and increasing total antioxidant capacity, and this positive effect is more obvious when yogurt contains fermented lactic acid S. platensis is consumed by T2DM patients.

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发酵螺旋藻对减少 2 型糖尿病患者氧化应激的有益影响

高血糖引起的氧化应激可导致高血糖加剧，增加糖尿病并发症的风险。螺旋藻是一种有效的自由基清除剂，可用作乳酸菌发酵的底物。本研究旨在为 2 型糖尿病（T2DM）患者配制两种具有抗氧化能力的功能性食品（含板蓝根螺旋藻粉的酸奶/发酵板蓝根螺旋藻粉），并比较其在糖尿病受试者中的抗氧化效果。本文首次在 "T2DM "患者的临床研究中比较了发酵螺旋藻和非发酵螺旋藻的抗氧化效果。通过抽血，测量了每次治疗前后的 FBS、GSH、FRAP、MDA 和 CRP 等临床参数，并对两组干预结果进行了比较。这两种产品作为功能性食品对糖尿病患者的健康都有积极作用，能降低 FBS 并提高总抗氧化能力，而 T2DM 患者食用含有发酵乳酸菌 S. platensis 的酸奶后，这种积极作用更加明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.