Biomarkers and Prognostic Stratification of Squamous Cell Carcinoma of the Oral Cavity in Young Adults: how to personalize therapeutic management?

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-09-19 DOI:10.1158/1055-9965.EPI-24-1091

Antoine Dubray-Vautrin, Guillaume Rougier, Christophe Le Tourneau, Wahib Ghanem, Nathalie Badois, Maria Lesnik, Baptiste Sabran, Laurence Bozec, Joey Martin, Olivier Choussy

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Abstract

Squamous cell carcinomas (SCCs) of the oral cavity in young adults represent a heterogeneous entity. New prognostic biomarkers are described in the literature. The aim was to identify emerging biomarkers and prognostic stratification factors of young population. Clinical, biological, microbiological, histopathological, and molecular markers statistically associated with overall and disease-free survival (OS) and validated in literature. Young adults < 40 years who were non-smokers showed a marginally worse prognosis, while age < 30 years was unfavorable compared to > 30 years. High rate of Neutrophil-to-lymphocyte ratio (NLR) was associated with decreased 5-year disease-specific survival, PDL1 expression correlated with improved OS and recurrence-free survival, presence of Fusobacterium, Mutations in p53, Cyclin D1, and VEGF was associated with reduced OS. Combining these markers in young adult oral cavity SCCs should be used to adapt the intensification of therapy in addition to the TNM classification and minor histo-prognostic factors.

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年轻人口腔鳞状细胞癌的生物标志物和预后分层：如何进行个性化治疗？

青壮年口腔鳞状细胞癌（SCC）是一种异质性肿瘤。文献中描述了新的预后生物标志物。研究的目的是确定新出现的生物标志物和年轻人群的预后分层因素。临床、生物学、微生物学、组织病理学和分子标记与总生存期和无病生存期（OS）相关，并在文献中得到验证。年龄小于40岁且不吸烟的年轻人预后稍差，而年龄小于30岁的年轻人预后比大于30岁的年轻人差。中性粒细胞与淋巴细胞比值（NLR）高与5年疾病特异性生存率降低有关，PDL1表达与OS和无复发生存率改善有关，Fusobacterium、p53、Cyclin D1和VEGF突变与OS降低有关。除了TNM分类和次要组织预后因素外，还应结合这些标记物来调整年轻成人口腔SCC的强化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.