Carbohydrate quality index and risk of non-alcoholic fatty liver disease in Iranian adults.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Mitra Kazemi Jahromi, Niloufar Saber, Mostafa Norouzzadeh, Ghazal Daftari, Fatemeh Pourhabibi-Zarandi, Hamid Ahmadirad, Hossein Farhadnejad, Farshad Teymoori, Ammar Salehi-Sahlabadi, Parvin Mirmiran
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Abstract

Background/aim: In the current study, we aimed to assess the association of carbohydrate quality index (CQI) with the risk of non-alcoholic fatty liver disease (NAFLD) in Iranian adults.

Methods: This case-control study was conducted on 225 newly diagnosed NAFLD patients and 450 controls, aged 20-60 years. A food frequency questionnaire was used to calculate the CQI and its components, including fiber intake, glycemic index, whole grains: total grains ratio, and solid carbohydrates: total carbohydrates ratio. Multivariable logistic regression was used to estimate the odds ratio (OR) of NAFLD across the tertile of CQI and its components.

Results: The participant's mean ± SD of body mass index and age were 26.8 ± 4.3 kg/m2 and 38.1 ± 8.8 years, respectively. The median (interquartile) CQI score in participants of the case and control groups was 20 (15-25) and 23 (18-28), respectively. In the multivariable-adjusted model, the risk of NAFLD decreased significantly across the tertiles of the CQI [(OR: 0.20; %95CI: 0.11-0.39), Ptrend <0.001)]. Also, the odds of NAFLD decreased across tertiles of solid carbohydrates to total carbohydrates ratio [(OR: 0.39; 95%CI: 0.22-0.69), Ptrend <0.001)]. However, a high dietary glycemic index (GI) was associated with increased odds of NAFLD [(OR:7.47; 95%CI: 3.89-14.33, Ptrend<0.001)]. There was no significant relationship between other CQI components, including fiber intake and whole grain/total grains and the risk of NAFLD.

Conclusions: Our results revealed that a diet with a high quality of carbohydrates, characterized by higher intakes of solid carbohydrates, whole grain, and low GI carbohydrates, can be related to a reduced risk of NAFLD.

伊朗成年人的碳水化合物质量指数与非酒精性脂肪肝的风险。
背景/目的:本研究旨在评估碳水化合物质量指数(CQI)与伊朗成年人罹患非酒精性脂肪肝(NAFLD)风险的关系:这项病例对照研究的对象是 225 名新确诊的非酒精性脂肪肝患者和 450 名对照者,年龄在 20-60 岁之间。采用食物频率调查问卷计算CQI及其组成部分,包括纤维摄入量、血糖生成指数、全谷物:总谷物比率和固体碳水化合物:总碳水化合物比率。采用多变量逻辑回归法估算非酒精性脂肪肝在不同CQI及其组成成分中的几率比(OR):参与者体重指数和年龄的平均值(± SD)分别为 26.8 ± 4.3 kg/m2 和 38.1 ± 8.8 岁。病例组和对照组参与者的 CQI 得分中位数(四分位间)分别为 20(15-25)和 23(18-28)。在经多变量调整的模型中,非酒精性脂肪肝的风险在CQI的四分位数上显著降低[(OR:0.20;%95CI:0.11-0.39),Ptrend趋势结论:我们的研究结果表明,碳水化合物质量高(固体碳水化合物、全谷物和低 GI 碳水化合物的摄入量较高)的饮食与非酒精性脂肪肝风险的降低有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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