A real-world data analysis of distribution and inconsistency between total serum IgE and allergen-specific IgE results in clinical practice.

IF 2.3 4区 医学 Q3 ALLERGY
Xianjie Yang, Zhiqiang Song, Shifei Li, Anqi Chen, Huan Wang, Sisi Deng, Bing Ni, Qiquan Chen
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引用次数: 0

Abstract

Background: The inconsistency between serum total IgE (tIgE) and allergen-specific IgE (sIgE) results is often encountered in clinical practice, but the distribution and influencing factors of the inconsistent results have not been fully understood.

Objective: The aim of this study was to analyze the distribution and inconsistency between tIgE and sIgE test results.

Methods: A retrospective study, from the electronic medical records of 2139 patients who underwent both tIgE and sIgE tests, from January to December 2023 was reviewed. The tIgE and sIgE results and their distribution, as well as their inconsistency, were analyzed based on sex, age, and disease subgroups.

Results: 36.2% of the patients had a positive sIgE, and 43.7% had an elevated tIgE level. sIgE and tIgE results were discordant in nearly 30% of patients, with no difference between genders, while individuals aged over 60 exhibited a significantly higher inconsistency rate than the other age groups, and the inconsistency rate between tIgE and sIgE results was significantly different among different tIgE levels, sIgE grades, positive allergen count and positive allergen types. In addition, patients with chronic urticaria (CU) had a higher inconsistency rate than those with other allergic diseases, but the difference was not statistically significant.

Conclusion: The overall inconsistency rate between tIgE and sIgE results was about 30%. The elderly group older than 60 years old is more likely to have inconsistent results, and tIgE level, sIgE level, the number and type of positive allergens also affected the consistency of tIgE and sIgE results.

关于血清总 IgE 和过敏原特异性 IgE 结果在临床实践中的分布和不一致性的实际数据分析。
背景:临床上经常会遇到血清总IgE(tIgE)和过敏原特异性IgE(sIgE)检测结果不一致的情况,但其分布和影响因素尚未完全清楚:本研究旨在分析 tIgE 和 sIgE 检测结果的分布和不一致性:回顾性研究:研究人员查阅了 2023 年 1 月至 12 月期间 2139 名同时接受 tIgE 和 sIgE 检测的患者的电子病历。根据性别、年龄和疾病分组分析了 tIgE 和 sIgE 结果及其分布情况,以及它们的不一致性:36.2%的患者sIgE呈阳性,43.7%的患者tIgE水平升高。近30%的患者sIgE和tIgE结果不一致,性别之间无差异,而60岁以上人群的不一致率明显高于其他年龄组,不同tIgE水平、sIgE等级、阳性过敏原数量和阳性过敏原类型之间的tIgE和sIgE结果不一致率存在显著差异。此外,慢性荨麻疹(CU)患者的不一致率高于其他过敏性疾病患者,但差异无统计学意义:结论:tIgE 和 sIgE 结果的总体不一致率约为 30%。结论:tIgE 和 sIgE 结果的总体不一致率约为 30%,60 岁以上的老年人群更容易出现结果不一致的情况,tIgE 水平、sIgE 水平、阳性过敏原的数量和类型也会影响 tIgE 和 sIgE 结果的一致性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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