Predictive Value of the Naples Prognostic Score for Cardiovascular Outcomes in Patients With Chronic Kidney Disease Receiving Percutaneous Coronary Intervention.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2024-09-19 DOI:10.1177/00033197241285970

Xue Zhang, Jing-Kun Zhang, Xue Wu, Xing Liu, Tong Liu, Kang-Yin Chen

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Abstract

The Naples prognostic score (NPS) is a novel multidimensional inflammatory and nutritional assessment system in cancer patients. However, its significance in patients with chronic kidney disease (CKD) after percutaneous coronary intervention (PCI) remains unclear. The study has a single-center, retrospective design and included 631 patients with CKD who underwent index PCI between 2019 and 2022. All participants were divided into 2 groups according to the NPS (Low-risk group: n = 209; High-risk group: n = 422) and followed up until November 2022. The primary endpoint was Major Adverse Cardiac Events (MACE). NPS predicted MACE events better than other scores, besides, high-risk NPS with severe renal dysfunction (RD) group (MODEL 2) had superior MACE diagnostic efficiency than NPS high-risk group lonely. (NPS: AUC: 0.605, P < .001; MODEL 2: AUC: 0.624, P < .001, respectively). Kaplan-Meier survival analysis of two groups showed that high-risk group had higher incidence of MACE (P < .001). Meanwhile, high-risk group had higher MACE events [adjusted Hazard Ratio (aHR) 2.013, 95% CI 1.294, 3.132; P = .002]. NPS is an independent prognostic factor for CKD patients undergoing index PCI before operation whose predictive value for survival prognosis is better than other nutritional and inflammatory indicators. Compared with low NPS, patients with high NPS have a relatively poor prognosis.

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那不勒斯预后评分对接受经皮冠状动脉介入治疗的慢性肾病患者心血管预后的预测价值。

那不勒斯预后评分（NPS）是一种新型的癌症患者多维炎症和营养评估系统。然而，它对慢性肾脏病（CKD）患者经皮冠状动脉介入治疗（PCI）后的意义仍不明确。该研究采用单中心、回顾性设计，纳入了2019年至2022年期间接受指数PCI的631名CKD患者。所有参与者根据NPS分为两组（低风险组：n = 209；高风险组：n = 422），随访至2022年11月。主要终点是重大心脏不良事件（MACE）。NPS 预测 MACE 事件的效果优于其他评分，此外，伴有严重肾功能不全（RD）的高危 NPS 组（MODEL 2）的 MACE 诊断效果优于单独的 NPS 高危组。(NPS：AUC：0.605，P < .001；MODEL 2：AUC：0.624，P < .001）。两组的 Kaplan-Meier 生存分析显示，高危组的 MACE 发生率更高（P < .001）。同时，高危组有更高的 MACE 事件[调整危险比 (aHR) 2.013, 95% CI 1.294, 3.132; P = .002]。对于术前接受指数 PCI 的 CKD 患者来说，NPS 是一个独立的预后因素，其对生存预后的预测价值优于其他营养和炎症指标。与低 NPS 相比，高 NPS 患者的预后相对较差。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days