Hypothyroidism in Metabolic Syndrome.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2024-10-01 Epub Date: 2024-09-14 DOI:10.4103/aam.aam_25_24

Durga Prasad Verma, Shyam Chand Chaudhary, Abhishek Singh, Kamal Kumar Sawlani, Kamlesh Kumar Gupta, Kauser Usman, Himanshu Dandu Reddy, Munna Lal Patel, Sudhir Kumar Verma, Virendra Atam

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Abstract

Introduction: Metabolic syndrome (MetS) and hypothyroidism are well-established forerunners of atherogenic cardiovascular disease (CVD). It is possible that patients suffering from both these disease entities may have a compounded risk. This study aimed at determining the prevalence of hypothyroidism in MetS.

Materials and methods: This cross-sectional study was conducted from September 2017 to August 2018 in the department of medicine at a tertiary care hospital in Northern India. Ethical approval was obtained from the institutional ethical committee. The study subjects consisted of 157 patients with MetS, the diagnosis of which was based on the International Diabetes Federation criteria. After a detailed history and physical examination, relevant investigations including complete thyroid profile were done. The data were analyzed using appropriate statistical tests (P < 0.05).

Results: In our study, the age of subjects ranged between 14 and 92 years, with a mean ± standard deviation of 48.1 ± 17.01 years. There were more females than males with a male-to-female ratio of 1:1.3. The prevalence of hypothyroidism was 46.5%. Hypothyroidism was more common in females (58.9%) as compared to males (41.1%). Patients with hypothyroidism had significantly higher body weight and body mass index (BMI) in comparison to euthyroid patients. The rest of the anthropometric parameters were comparable. Waist circumference and BMI of overt hypothyroid patients were found to be higher as compared to subclinical hypothyroid patients. Total cholesterol and triglyceride were significantly higher (P = 0.001 and P < 0.001, respectively), while high-density lipoprotein levels were significantly lower in patients with hypothyroidism than the euthyroid group (P < 0.001).

Conclusion: Hypothyroidism, especially subclinical hypothyroidism, is a common endocrine disorder in patients with MetS. As MetS and hypothyroidism are independent risk factors for CVD, hence there is a need for screening for hypothyroidism and the treatment of the same can be beneficial in reducing the cardiovascular morbidity and mortality in patients with MetS.

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代谢综合征中的甲状腺功能减退症

简介代谢综合征（MetS）和甲状腺功能减退症是公认的致动脉粥样硬化性心血管疾病（CVD）的先驱。同时罹患这两种疾病的患者有可能面临更高的风险。本研究旨在确定甲状腺功能减退症在 MetS 中的患病率：这项横断面研究于 2017 年 9 月至 2018 年 8 月在印度北部一家三级医院的内科进行。研究获得了机构伦理委员会的伦理批准。研究对象包括 157 名 MetS 患者，其诊断基于国际糖尿病联盟标准。在详细询问病史和体格检查后，进行了包括完整甲状腺档案在内的相关检查。数据采用适当的统计学检验进行分析（P<0.05）：在我们的研究中，受试者的年龄介于 14 岁至 92 岁之间，平均年龄（± 标准差）为 48.1 岁（± 17.01）。女性多于男性，男女比例为 1:1.3。甲状腺功能减退症的发病率为 46.5%。与男性（41.1%）相比，甲状腺功能减退症在女性（58.9%）中更为常见。甲减患者的体重和体重指数（BMI）明显高于甲状腺功能正常的患者。其余人体测量参数与之相当。与亚临床甲减患者相比，显性甲减患者的腰围和体重指数较高。甲减患者的总胆固醇和甘油三酯明显较高（分别为P = 0.001和P < 0.001），而高密度脂蛋白水平则明显低于甲状腺功能正常组（P < 0.001）：甲状腺功能减退，尤其是亚临床甲状腺功能减退，是 MetS 患者常见的内分泌疾病。由于MetS和甲状腺功能减退症是心血管疾病的独立危险因素，因此有必要对甲状腺功能减退症进行筛查，治疗甲状腺功能减退症有助于降低MetS患者的心血管疾病发病率和死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

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0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.