Comparison of the effectiveness of neoadjuvant chemotherapy and adjuvant chemotherapy for improving prognosis in triple-negative breast cancer patients.

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI:10.62347/VHME8736
Wangbin Li, Yuwei Chang, Xiaohui Bai, Hongxin Cao
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引用次数: 0

Abstract

Objective: To compare the effectiveness of surgery combined with neoadjuvant chemotherapy and radiotherapy (SNCR) versus surgery combined with adjuvant chemotherapy and radiotherapy (SACR) in improving the prognosis of triple-negative breast cancer (TNBC) patients.

Methods: Clinical data from 112 TNBC patients treated between January 2014 and February 2019 were retrospectively collected. Data included clinical characteristics and 5-year disease-free survival (DFS). Kaplan-Meier (K-M) survival curves were used to analyze the associations of various factors with DFS. Lasso-Cox regression was used to screen significant variables identified by K-M survival analysis. Multivariate Cox regression was used to determine independent prognostic factors affecting DFS.

Results: K-M survival analysis showed that treatment regimen (P=0.012), TNM (tumor, node, metastasis) staging (P=0.049), N staging (P=0.015), P53 (P=0.015), KI-67 (P=0.002), neutrophil-to-lymphocyte ratio (NLR) (P<0.001), platelet-to-lymphocyte ratio (PLR) (P<0.001), and cancer antigen 153 (CA153) (P<0.001) were associated with DFS in TNBC patients. Lasso-Cox regression analysis identified treatment regimen, TNM stage, P53, KI-67, NLR, PLR, and CA153 as features related to DFS when λ=0.053741 (1se). Multivariate Cox regression analysis revealed that treatment regimen (P<0.001, 95% CI: 2.309-14.396, HR=5.765), P53 (P=0.010, 95% CI: 1.315-7.864, HR=3.216), and NLR (P=0.001, 95% CI: 2.098-14.553, HR=5.525) were independent prognostic factors affecting DFS. A nomogram model was constructed, and time-dependent receiver operating characteristic (ROC) curve analysis showed that the model's areas under the curve (AUC) for predicting 1-, 3-, and 5-year DFS were 0.928, 0.816, and 0.665, respectively.

Conclusion: The SNCR regimen significantly improves DFS in patients with stage IIb to IIIa TNBC compared to the traditional SACR regimen.

比较新辅助化疗和辅助化疗对改善三阴性乳腺癌患者预后的效果。
目的比较手术联合新辅助化疗和放疗(SNCR)与手术联合辅助化疗和放疗(SACR)在改善三阴性乳腺癌(TNBC)患者预后方面的效果:回顾性收集了2014年1月至2019年2月期间接受治疗的112例TNBC患者的临床数据。数据包括临床特征和5年无病生存期(DFS)。采用Kaplan-Meier(K-M)生存曲线分析各种因素与DFS的关系。Lasso-Cox 回归用于筛选 K-M 生存分析中发现的重要变量。多变量 Cox 回归用于确定影响 DFS 的独立预后因素:K-M生存分析显示,治疗方案(P=0.012)、TNM(肿瘤、结节、转移)分期(P=0.049)、N分期(P=0.015)、P53(P=0.015)、KI-67(P=0.002)、中性粒细胞与淋巴细胞比值(NLR)(PConclusion:与传统的SACR方案相比,SNCR方案可明显改善IIb至IIIa期TNBC患者的DFS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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