Markers of extracellular matrix degradation and inflammasome activation are associated with carotid plaques in virally suppressed people with HIV in Botswana.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-09-16 DOI:10.1097/QAD.0000000000004014

Thor Ueland, Isaac Nkele, Hedda Hoel, Shahin Lockman, Annika E Michelsen, Thato Moshomo, Pål Aukrust, Terence Mohammed, Marius Trøseid, Mosepele Mosepele

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引用次数: 0

Abstract

Background: HIV is associated with increased risk of cardiovascular disease. We investigated soluble markers of extracellular matrix (ECM) remodeling and inflammation in relation to presence of carotid plaques in a well-characterized adult cross-sectional study of people with HIV (PWH) and matched people without HIV in Botswana.

Methods: Using enzyme immunoassays we analyzed plasma ECM remodeling mediators including Galectin-3 (GAL-3), Cystatin B (CysB) and Growth/differentiation factor 15 (GDF-15) and the inflammatory marker IL-18 in 196 without HIV and 197 PWH of which 36 were ART-naïve.

Results: We found i) PWH had higher plasma levels of the ECM markers GAL-3 and CysB and the NLRP3 inflammasome activation marker IL-18, mainly in ART naïve participants, ii) PWH on ART had markedly higher GDF-15, associated with use of first generation nucleoside analogs; iii) high levels of CysB and IL-18 correlated with presence of carotid plaques.

Conclusion: In PWH, high levels of CysB and IL-18 were associated with the presence of carotid plaques. For IL-18 this was observed in the study population as a whole, while the association for CysB was restricted to PWH.

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在博茨瓦纳，细胞外基质降解和炎症小体激活标志物与病毒抑制的艾滋病病毒感染者颈动脉斑块有关。

背景：艾滋病与心血管疾病风险增加有关。我们在博茨瓦纳对艾滋病毒感染者（PWH）和未感染艾滋病毒的匹配人群进行了一项特征明确的成人横断面研究，调查了细胞外基质（ECM）重塑和炎症与颈动脉斑块存在的关系：我们使用酶免疫测定法分析了血浆 ECM 重塑介质（包括 Galectin-3 (GAL-3)、胱抑素 B (CysB)、生长/分化因子 15 (GDF-15)）和炎症标志物 IL-18：我们发现 i) PWH 的血浆中 ECM 标志物 GAL-3 和 CysB 以及 NLRP3 炎性体活化标志物 IL-18 的水平较高，主要是在抗逆转录病毒疗法未接受治疗的参与者中；ii) 接受抗逆转录病毒疗法的 PWH 的 GDF-15 水平明显较高，这与使用第一代核苷类似物有关；iii) CysB 和 IL-18 的高水平与颈动脉斑块的存在相关：结论：在 PWH 中，高水平的 CysB 和 IL-18 与颈动脉斑块的存在有关。结论：在 PWH 患者中，高水平的 CysB 和 IL-18 与颈动脉斑块的存在有关，IL-18 与整个研究人群有关，而 CysB 与颈动脉斑块的相关性仅限于 PWH。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.