Increased extracellular free water is related to white matter hyperintensity burden.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Acta radiologica Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI:10.1177/02841851241282085

Xinjun Lei, Weiwen Qiu, Zhihua Xu, Jie Yu, Haiyuan Lan

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引用次数: 0

Abstract

Background: Extracellular free water (FW) has important roles in the occurrence and development of white matter hyperintensity (WMH).

Purpose: To explore the correlations between FW and WMH burden.

Material and methods: A prospective analysis was conducted using magnetic resonance imaging (MRI) data from 126 individuals. WMH burden was determined based on WMH volumes and Fazekas scores from deep and periventricular white matter hyperintensity (DWMH and PWMH, respectively) in fluid-attenuated inversion recovery (FLAIR) images. FW values were taken from diffusion tensor imaging (DTI).

Results: Univariate analysis showed that FW values were correlated with WMH burden, including WMH volumes and DWMH and PWMH Fazekas scores (P < 0.05). After multivariate analysis, FW values were correlated with WMH volumes and DWMH and PWMH Fazekas scores when adjusted for age and hypertension (P < 0.05).

Conclusion: Using MRI, increasing extracellular FW was related to WMH burden.

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细胞外游离水的增加与白质高密度负荷有关。

背景：目的：探讨细胞外游离水（FW）与白质高密度（WMH）之间的相关性：利用 126 人的磁共振成像（MRI）数据进行了前瞻性分析。WMH负荷是根据液体减弱反转恢复（FLAIR）图像中深部和脑室周围白质高密度（分别为DWMH和PWMH）的WMH体积和Fazekas评分确定的。FW值来自扩散张量成像（DTI）：单变量分析表明，FW值与WMH负荷相关，包括WMH体积、DWMH和PWMH Fazekas评分（P P 结论：细胞外FW值的增加与WMH负荷有关：通过磁共振成像，细胞外FW的增加与WMH负荷有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta radiologica 医学-核医学

CiteScore

2.70

自引率

0.00%

发文量

170

审稿时长

3-8 weeks

期刊介绍： Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.