Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress.

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2024-11-25 Epub Date: 2024-09-10 DOI:10.1016/j.scitotenv.2024.176187

Zuhai Chen, Wanting Wei, Yunhua Hu, Qiang Niu, Yizhong Yan

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引用次数: 0

Abstract

Background: Per- and polyfluoroalkyl substances (PFAS) pose potential risks to human health. In real-world settings, humans are exposed to various PFAS through numerous pathways.

Objectives: This study evaluated the associations between co-exposure to PFAS and obesity and its comorbidities, along with the mediating roles of inflammation and oxidative stress.

Methods: We analyzed 11,090 participants from National Health and Nutrition Examination Survey (NHANES), 2003-2018. Linear regression, logistic regression, and generalized additive models were used to assess the individual effects of PFAS exposure on obesity and its comorbidities. The environmental risk score (ERS) was calculated using the adaptive elastic-net model to assess the co-exposure effects. Linear and logistic regression models explored the associations between ERS and obesity and its comorbidities. Mediation analyses explored the roles of inflammatory (neutrophils, lymphocytes, and alkaline phosphatase) and oxidative stress (gamma-glutamyl transferase, total bilirubin, and uric acid) markers in the associations between ERS and obesity and its comorbidities.

Results: For each unit increase in ERS, the odds of obesity and type 2 diabetes mellitus (T2DM) increased 3.60-fold (95 % CI: 2.03, 6.38) and 1.91-fold (95 % CI: 1.28, 2.86), respectively. For each unit increase in ERS, BMI increased by 2.36 (95 % CI: 1.24, 3.48) kg/m², waist circumference increased by 6.47 (95 % CI: 3.56, 9.37) cm, and waist-to-height ratio increased by 0.04 (95 % CI: 0.02, 0.06). Lymphocytes, alkaline phosphatase, and total bilirubin were significantly associated with both ERS and obesity, with mediation proportions of 4.17 %, 3.62 %, and 7.37 %, respectively. Lymphocytes, alkaline phosphatase, total bilirubin, and uric acid were significantly associated with both ERS and T2DM, with the mediation proportions of 8.90 %, 8.74 %, 29.73 %, and 38.19 %, respectively.

Conclusions: Co-exposure to PFAS was associated with obesity and T2DM, and these associations may be mediated by inflammation and oxidative stress. Further mechanistic and prospective studies are required to verify these associations.

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共同暴露于全氟和多氟烷基物质与代谢性疾病之间的关系：炎症和氧化应激的中介作用。

背景：全氟烷基和多氟烷基物质（PFAS）对人类健康构成潜在风险。在现实世界中，人类通过多种途径接触到各种 PFAS：本研究评估了共同暴露于 PFAS 与肥胖及其合并症之间的关联，以及炎症和氧化应激的中介作用：我们分析了 2003-2018 年美国国家健康与营养调查（NHANES）的 11,090 名参与者。我们采用线性回归、逻辑回归和广义相加模型来评估PFAS暴露对肥胖及其合并症的个体影响。采用自适应弹性网模型计算环境风险评分（ERS），以评估共同暴露效应。线性回归和逻辑回归模型探讨了ERS与肥胖症及其合并症之间的关联。中介分析探讨了炎症指标（中性粒细胞、淋巴细胞和碱性磷酸酶）和氧化应激指标（γ-谷氨酰转移酶、总胆红素和尿酸）在 ERS 与肥胖及其合并症之间关系中的作用：ERS每增加一个单位，肥胖和 2 型糖尿病（T2DM）的几率分别增加 3.60 倍（95 % CI：2.03, 6.38）和 1.91 倍（95 % CI：1.28, 2.86）。ERS 每增加一个单位，体重指数（BMI）增加 2.36（95 % CI：1.24，3.48）千克/平方米，腰围增加 6.47（95 % CI：3.56，9.37）厘米，腰高比增加 0.04（95 % CI：0.02，0.06）。淋巴细胞、碱性磷酸酶和总胆红素与 ERS 和肥胖均有显著相关性，中介比例分别为 4.17%、3.62% 和 7.37%。淋巴细胞、碱性磷酸酶、总胆红素和尿酸与 ERS 和 T2DM 均有显著相关性，中介比例分别为 8.90 %、8.74 %、29.73 % 和 38.19 %：共同暴露于全氟辛烷磺酸与肥胖和 T2DM 有关，这些关联可能是由炎症和氧化应激介导的。需要进一步的机理研究和前瞻性研究来验证这些关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.