Ratiometric fluorescence sensing and discrimination of tetracycline analogs by using coumarin-embedded Eu-MOF nanosensor.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI:10.1016/j.talanta.2024.126914

Peng-Xiang Yuan, Yu-Ping Wang, Fangfang Du, Liu-Pan Yang, Li-Li Wang

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引用次数: 0

Abstract

As widely used antibiotics, tetracycline residues exist in food and environmental media, which pose certain hidden dangers and negative effects on public health. Therefore, the sensing and discrimination of tetracycline analogs (TCs) have great significance for improving food safety and preventing environmental pollution. Herein, a 7-hydroxycoumarin-3-carboxylic acid-embedded Eu-MOF (HC@Eu-MOF) material was constructed and then developed for the detection of TCs. Upon addition of TCs, the synthesized sensor displays opposite fluorescence changes at two different wavelengths due to the simultaneous presence of the inner filter effect (IFE) and the antenna effect (AE), and achieves a stable ratio signal response within 90 s. In addition, six important tetracycline analogs, including chlortetracycline (CTC), oxytetracycline (OTC), tetracycline (TC), metacycline (MC), doxycycline (DC) and demeclocycline (DMC) can be discriminated with 100 % accuracy through the principal component analysis even in extremely complicated mixtures. Further, a smartphone-assisted portable device was applied for visual sensing of TCs. The as-developed platform possessed the characteristics of simple synthesis, fast response, high sensitivity, and high stability, which further lays a further foundation for the on-site visual detection and discrimination of TCs in real samples.

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利用香豆素嵌入式 Eu-MOF 纳米传感器对四环素类似物进行比率荧光传感和鉴别。

作为广泛使用的抗生素，四环素残留存在于食品和环境介质中，对公众健康造成一定的隐患和负面影响。因此，四环素类似物（TCs）的检测和鉴别对于提高食品安全和防止环境污染具有重要意义。本文构建了一种 7-羟基香豆素-3-羧酸包埋 Eu-MOF （HC@Eu-MOF）材料，并将其用于 TCs 的检测。加入三氯甲烷后，由于同时存在内滤波效应（IFE）和天线效应（AE），合成的传感器在两个不同波长上显示出相反的荧光变化，并在 90 秒内实现了稳定的比值信号响应。此外，六种重要的四环素类似物，包括金霉素（CTC）、土霉素（OTC）、四环素（TC）、甲环素（MC）、强力霉素（DC）和去甲环素（DMC），即使在极其复杂的混合物中，也能通过主成分分析以 100% 的准确率进行鉴别。此外，还将智能手机辅助便携式设备应用于 TC 的视觉感测。该平台具有合成简单、响应速度快、灵敏度高、稳定性强等特点，为现场目测和鉴别实际样品中的三氯甲烷奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.