Electrochemical sensor featuring PdFeCo_1-xONPs on carbon paper for the sensitive determination of indole-3-lactic acid levels in serum samples.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-01 Epub Date: 2024-09-21 DOI:10.1016/j.talanta.2024.126919

Dieudonne Tanue Nde, Dhananjaya Merum, Gyawali Ghanashyam, Jean Pierre Ndabakuranye, Mohamed A Habila, Arghya Narayan Banerjee, Sang Woo Joo, Theophile Niyitanga, Haekyoung Kim

{"title":"Electrochemical sensor featuring PdFeCo1-xONPs on carbon paper for the sensitive determination of indole-3-lactic acid levels in serum samples.","authors":"Dieudonne Tanue Nde, Dhananjaya Merum, Gyawali Ghanashyam, Jean Pierre Ndabakuranye, Mohamed A Habila, Arghya Narayan Banerjee, Sang Woo Joo, Theophile Niyitanga, Haekyoung Kim","doi":"10.1016/j.talanta.2024.126919","DOIUrl":null,"url":null,"abstract":"A highly sensitive and selective electrochemical sensing platform with self-assembled porous 3-D trimetallic (Pd, Fe, and Co) hybrid anchored on a cost-effective and high-conducting carbon paper (CP) synthesized via a facile and cost-effective hydrothermal impregnation and thermal reduction technique was developed for determining indole-3-lactic acid (ILA) levels in buffer and serum samples. Before the analytical phase, the composite (PdFeCo1-xONPs@CP electrode) was thoroughly characterized, and different methods were used to investigate the electrochemical properties. The combination of tri-metallics with CP-fibers improved sensing capacities in the linear range of 0.05-30 μM, with sensitivity and limits of detection of and 0.165 ± 0.013 μA/μM and 7.8 ± 0. 2 nM, respectively, towards ILA determination. Furthermore, the developed sensing platform was utilized for the analyses of ILA in sigma, human normal, and alcohol use disorder patients' serum samples. Liquid chromatography in tandem with mass spectrometry was equally used to quantify ILA levels in the serum samples and the results of both methods were compared.","PeriodicalId":435,"journal":{"name":"Talanta","volume":null,"pages":null},"PeriodicalIF":5.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.talanta.2024.126919","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

A highly sensitive and selective electrochemical sensing platform with self-assembled porous 3-D trimetallic (Pd, Fe, and Co) hybrid anchored on a cost-effective and high-conducting carbon paper (CP) synthesized via a facile and cost-effective hydrothermal impregnation and thermal reduction technique was developed for determining indole-3-lactic acid (ILA) levels in buffer and serum samples. Before the analytical phase, the composite (PdFeCo_1-xONPs@CP electrode) was thoroughly characterized, and different methods were used to investigate the electrochemical properties. The combination of tri-metallics with CP-fibers improved sensing capacities in the linear range of 0.05-30 μM, with sensitivity and limits of detection of and 0.165 ± 0.013 μA/μM and 7.8 ± 0. 2 nM, respectively, towards ILA determination. Furthermore, the developed sensing platform was utilized for the analyses of ILA in sigma, human normal, and alcohol use disorder patients' serum samples. Liquid chromatography in tandem with mass spectrometry was equally used to quantify ILA levels in the serum samples and the results of both methods were compared.

查看原文本刊更多论文

碳纸上的 PdFeCo1-xONP 电化学传感器用于灵敏测定血清样品中的吲哚-3-乳酸含量。

为了测定缓冲液和血清样品中吲哚-3-乳酸（ILA）的含量，研究人员开发了一种高灵敏度和高选择性的电化学传感平台，该平台将自组装多孔三维三金属（钯、铁和钴）杂化物锚定在通过简便、经济的水热浸渍和热还原技术合成的高导电碳纸（CP）上。在进入分析阶段之前，对复合材料（PdFeCo1-xONPs@CP 电极）进行了全面的表征，并采用不同的方法研究其电化学特性。三金属与 CP 纤维的结合提高了在 0.05-30 μM 线性范围内的传感能力，对 ILA 检测的灵敏度和检出限分别为 0.165 ± 0.013 μA/μM 和 7.8 ± 0.2 nM。此外，还利用所开发的传感平台分析了 sigma、正常人和酒精使用障碍患者血清样本中的 ILA。液相色谱串联质谱法同样用于定量检测血清样本中的 ILA 含量，并对两种方法的结果进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.