gem-Difluoroallene (DFA): an emerging versatile synthetic precursor to enable diverse fluorinated molecules

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Kota Sathish, Swati Jain, Naveen Sihag and M. Ramu Yadav
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引用次数: 0

Abstract

Organofluorine compounds are increasingly found in diverse fields, such as pharmaceuticals, agrochemicals, and materials science. gem-Difluoroallenes, which have gem-difluoro alkenes and allenes-like properties, offer a distinct and adaptable platform for novel synthetic transformations. Their distinctiveness is highlighted by various strategies, where the gem-difluoro group's presence plays a pivotal role in successful reactions. This review article presents a comprehensive overview of the latest progress in utilizing gem-difluoroallenes for selective additions, defluorination, as well as cycloaddition and cyclization reactions. We also discuss the limitations and future directions in this area, inspiring further exploration and innovation.

Abstract Image

gem-二氟甲苯 (DFA):一种新兴的多功能合成前体,可生成多种氟化分子。
有机氟化合物越来越多地出现在医药、农用化学品和材料科学等不同领域。具有宝石-二氟烯烃和类烯特性的宝石-二氟烯烃为新型合成转化提供了一个独特且适应性强的平台。它们的独特性通过各种策略得以凸显,在这些策略中,宝石-二氟基团的存在在成功反应中起着关键作用。这篇综述文章全面概述了利用宝石二氟烯类进行选择性加成、脱氟以及环加成和环化反应的最新进展。我们还讨论了这一领域的局限性和未来发展方向,激励人们进一步探索和创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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