{"title":"A wearable exhaled breath condensate (EBC) collector with controllable condensation microfluidics and a branched hydrophilic film","authors":"Chun-Hao Chang, Ying-Hsuan Yu, Hsiu-Pen Lin, Ping-Hsien Tsou, Yaw-Kuen Li, Bor-Ran Li","doi":"10.1016/j.cej.2024.155994","DOIUrl":null,"url":null,"abstract":"In previous research, exhaled breath condensate (EBC) analysis has emerged as a promising noninvasive method for assessing human health, potentially increasing patient testing acceptance. However, current EBC collection devices require cooling equipment for temperature reduction, leading to issues such as increased size, increased energy consumption, and a lack of real-time collection capability. In this study, an EBC collector was developed that integrates controllable condensation microfluidics with a biomimetic water-collecting film. Microfluids induce an endothermic reaction by rapidly dissolving water and NH<ce:inf loc=\"post\">4</ce:inf>NO<ce:inf loc=\"post\">3</ce:inf> within the chamber, reducing the surface temperature to 3.5 °C. When positioned inside a mask, exhaled air undergoes condensation and collection on the branched biomimetic film. Human tests were conducted to analyze caffeine and nicotine in the collected EBC samples using LC–MS, demonstrating the device’s advantages in terms of power-free operation, wearable design, and rapid sample collection for metabolite detection.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":null,"pages":null},"PeriodicalIF":13.3000,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.cej.2024.155994","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
In previous research, exhaled breath condensate (EBC) analysis has emerged as a promising noninvasive method for assessing human health, potentially increasing patient testing acceptance. However, current EBC collection devices require cooling equipment for temperature reduction, leading to issues such as increased size, increased energy consumption, and a lack of real-time collection capability. In this study, an EBC collector was developed that integrates controllable condensation microfluidics with a biomimetic water-collecting film. Microfluids induce an endothermic reaction by rapidly dissolving water and NH4NO3 within the chamber, reducing the surface temperature to 3.5 °C. When positioned inside a mask, exhaled air undergoes condensation and collection on the branched biomimetic film. Human tests were conducted to analyze caffeine and nicotine in the collected EBC samples using LC–MS, demonstrating the device’s advantages in terms of power-free operation, wearable design, and rapid sample collection for metabolite detection.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.