Attitudes of patients with IVF/ICSI toward human embryo in vitro culture beyond 14 days

IF 3.4 3区 环境科学与生态学 Q3 CELL & TISSUE ENGINEERING
Yukitaka Kiya , Saori Watanabe , Kana Harada , Hideki Yui , Yoshimi Yashiro , Kaori Muto
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引用次数: 0

Abstract

When the International Society for Stem Cell Research revised its 2021 guidelines, it reversed its ban on the in vitro culture of human embryos beyond 14 days. However, despite widespread recognition of the importance of public debate on embryo research, it remains unclear how patients who have undergone in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) perceive this change in the guidelines. Three focus group interviews were conducted with IVF/ICSI patients to understand their opinions on extending the in vitro culture of human embryos beyond 14 days. Thematic analysis revealed a primarily favorable attitude toward the extension of in vitro embryo culture, identifying six reasons for this positive perspective. However, two reasons for negative attitudes were identified, along with some concerns that need to be addressed. To facilitate an open discussion, the following suggestions were made to the government and scientific community. The government and scientific community should provide sufficient knowledge to IVF/ICSI patients about research before discussions. It's important to consider diverse views on embryo models, including distrust and resistance. Ensuring IVF/ICSI patients' psychological safety is essential. “Public conversations” with citizens, including IVF/ICSI patients, should be promoted, and their opinions should be considered as part of a broader public spectrum.

IVF/ICSI 患者对人类胚胎体外培养超过 14 天的态度
国际干细胞研究学会在修订其 2021 年指导方针时,撤销了对人类胚胎体外培养超过 14 天的禁令。然而,尽管人们普遍认识到就胚胎研究进行公开辩论的重要性,但接受体外受精(IVF)和/或卵胞浆内单精子显微注射(ICSI)的患者如何看待指南中的这一变化仍不清楚。我们对 IVF/ICSI 患者进行了三次焦点小组访谈,以了解他们对将人类胚胎体外培养延长至 14 天以上的看法。主题分析表明,他们对延长体外胚胎培养的时间主要持赞成态度,并为这种积极观点找出了六个原因。不过,也发现了两个持否定态度的原因,以及一些需要解决的问题。为了促进公开讨论,向政府和科学界提出了以下建议。政府和科学界应在讨论前向 IVF/ICSI 患者提供足够的研究知识。必须考虑对胚胎模型的不同看法,包括不信任和抵制。确保 IVF/ICSI 患者的心理安全至关重要。应促进与包括 IVF/ICSI 患者在内的公民进行 "公开对话",并将他们的意见作为更广泛的公众范围的一部分加以考虑。
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来源期刊
Regenerative Therapy
Regenerative Therapy Engineering-Biomedical Engineering
CiteScore
6.00
自引率
2.30%
发文量
106
审稿时长
49 days
期刊介绍: Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.
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