Luminescence sensing of narcotic drugs by a BSA protein stabilized AuAgCd trimetallic nanocluster

Next Nanotechnology Pub Date : 2024-09-21 DOI:10.1016/j.nxnano.2024.100107

Shashikana Paria, Prasenjit Maity

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Abstract

A luminescent trimetiallic nanocluster (NCs) stabilized by BSA protein (AuAgCd-BSA) was synthesized along with its mono and bimetallic counterparts (Au-BSA and AuAg-BSA). The detail characterization and comparative luminescence sensing performance for narcotic drugs and psychotropic substance (amphetamine, morphine) were performed for these three clusters. It was revealed that the trimetallic cluster can detect amphetamine and morphine drugs through turn on luminescence response. The calculated binding constants are found to be K_a = 5.86× 10³ M⁻¹ for Amphetamine and 3.75× 10³ M⁻¹ for Morphine by using Benesi-Hildebrand equation. The trimetallic cluster also showed selective turn off luminescence response in presence of mercury (Hg²⁺) ions. The origin of the enhanced PL responses in presence of amphetamine and morphine was further investigated by exploring the PL lifetime decay studies, which reveals that larger excited state lifetime (in μs timescale) value of pristine cluster remain unchanged upon incremental addition of drugs leading to longer interaction time with the analytes. Thus, the present work undoubtedly establishes the superior drug sensing behaviour of AuAgCd-BSA tri-metallic NCs as compared to its mono-metallic and bi-metallic counterparts and open further emphasis on exploring luminescence-based sensing of narcotic drugs which has great forensic relevance.

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用 BSA 蛋白稳定的 AuAgCd 三金属纳米簇对麻醉药物进行发光传感

研究人员合成了由 BSA 蛋白（AuAgCd-BSA）稳定的发光三金属纳米簇（NCs）及其单金属和双金属对应物（Au-BSA 和 AuAg-BSA）。研究人员对这三种簇合物进行了详细表征，并比较了它们对麻醉药品和精神药物（苯丙胺、吗啡）的发光传感性能。结果表明，三金属簇可以通过开启发光响应来检测苯丙胺和吗啡类药物。利用贝内西-希尔德布兰德方程计算得出的结合常数为：苯丙胺为 Ka = 5.86× 103 M-1，吗啡为 3.75× 103 M-1。在汞（Hg2+）离子存在的情况下，三金属簇也显示出选择性熄灭发光反应。通过对聚光寿命衰减的研究，我们进一步探究了苯丙胺和吗啡存在时聚光响应增强的原因，结果表明，原始簇簇的激发态寿命（μs 时间尺度）值在添加药物后保持不变，从而延长了与分析物的相互作用时间。因此，与单金属和双金属对应物相比，本研究工作无疑证明了 AuAgCd-BSA 三金属 NCs 优越的药物传感性能，并进一步强调了探索基于发光的麻醉药物传感具有重要的法医学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Next Nanotechnology

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