Risk factors for secondary epilepsy following febrile seizures in children: A meta-analysis

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Jing Zhang , Qiaomei Jing , Shangbin Li , Ye Liu , Zhe Lin , Xinyu Han , Ge Xu , Sihua Dai , Jing Zhang , Changjun Ren
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引用次数: 0

Abstract

Objective

To systematically assess the risk factors for secondary epilepsy in children with febrile seizures, in order to promptly identify early signs of epilepsy and establish a reliable foundation for timely clinical intervention and improved prognosis.

Methods

The databases, including CNKI, WanFang, VIP, CBM, PubMed, Embase, Web of Science, and the Cochrane Library were searched for relevant studies, up to October 2023. Two researchers independently collected and extracted data from selected studies, adhering to predefined criteria. Statistical analysis was performed using Stata 15.0.

Results

A total of 23 studies included 714 cases in the case group and 5269 cases in the control group. The results of Meta-analysis showed that preterm birth (OR=3.30, P=0.02), history of perinatal asphyxia (OR=3.94, P=0.001), age at the first seizure < 12 months (OR=2.93, P=0.003), peak temperature < 39℃ (OR=2.51, P<0.001), onset of fever to seizure < 1 h (OR=5.61, P<0.001), Complex FS(OR=4.08, P<0.001), duration of the seizure > 15 min (OR=6.21, P<0.001), Multiple seizures (≥2/episode) in one attack (OR=2.92, P<0.001), focal seizures (OR=2.53, P=0.018), recurrent FS (≥2) (OR=3.49, P<0.001), neurodevelopmental abnormality(OR=8.68, P<0.001), developmental delay(OR=10.04, P<0.001), family history of epilepsy (OR=2.74, P=0.004), family history of FS (OR=2.07, P=0.022), electroencephalogram (EEG) abnormal(OR=4.06, P<0.001)and Brain imaging abnormalities (OR=2.84, P=0.002)were Risk factors for secondary epilepsy following FS in Children. Notably, gender (female) was not a significant factor.

Conclusions

This study provides a comprehensive and systematic discussion of the risk factors associated with secondary epilepsy in children with febrile seizures. It actively formulates intervention measures for modifiable risk factors and conducts early detection and continuous follow-up observation for non-modifiable high-risk children, thereby reducing the risk of epilepsy.

儿童发热性癫痫发作后继发癫痫的风险因素:荟萃分析
目的系统评估发热性癫痫发作患儿继发性癫痫的危险因素,以便及时发现癫痫的早期征兆,为及时临床干预和改善预后奠定可靠的基础。方法检索 CNKI、万方、VIP、CBM、PubMed、Embase、Web of Science 和 Cochrane Library 等数据库中截至 2023 年 10 月的相关研究。两名研究人员按照预先设定的标准独立收集和提取所选研究的数据。结果 共有 23 项研究,病例组中有 714 例,对照组中有 5269 例。Meta 分析结果显示,早产(OR=3.30,P=0.02)、围产期窒息史(OR=3.94,P=0.001)、首次发作年龄 < 12 个月(OR=2.93,P=0.003)、最高体温 < 39℃(OR=2.51,P<0.001)、发热开始至发作<1 h(OR=5.61,P<0.001)、复杂FS(OR=4.08,P<0.001)、发作持续时间>15 min(OR=6.21,P<0.001)、一次发作中多次发作(≥2次/次)(OR=2.92,P<0.001)、局灶性癫痫发作(OR=2.53,P=0.018)、反复发作的 FS(≥2 次)(OR=3.49,P<0.001)、神经发育异常(OR=8.68,P<0.001)、发育迟缓(OR=10.04,P<0.001)、癫痫家族史(OR=2.74,P=0.004)、FS家族史(OR=2.07,P=0.022)、脑电图(EEG)异常(OR=4.06,P<0.001)和脑成像异常(OR=2.84,P=0.002)是儿童FS后继发性癫痫的危险因素。结论 本研究全面系统地探讨了热性惊厥儿童继发性癫痫的相关危险因素。积极针对可改变的风险因素制定干预措施,对不可改变的高危儿童进行早期发现和持续随访观察,从而降低癫痫风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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