Normative atlases of high-frequency oscillation and spike rates under Sevoflurane anesthesia

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-09-13 DOI:10.1016/j.clinph.2024.09.004

Hiroshi Uda , Naoto Kuroda , Ethan Firestone , Riyo Ueda , Kazuki Sakakura , Yu Kitazawa , Dominik Choromanski , Michael Cools , Aimee F. Luat , Eishi Asano

{"title":"Normative atlases of high-frequency oscillation and spike rates under Sevoflurane anesthesia","authors":"Hiroshi Uda , Naoto Kuroda , Ethan Firestone , Riyo Ueda , Kazuki Sakakura , Yu Kitazawa , Dominik Choromanski , Michael Cools , Aimee F. Luat , Eishi Asano","doi":"10.1016/j.clinph.2024.09.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>We analyzed the dose-dependent effects of Sevoflurane anesthesia on high-frequency oscillations (HFOs) and spike discharges at non-epileptic sites and evaluated their effectiveness in identifying the epileptogenic zone.</p></div><div><h3>Methods</h3><p>We studied 21 children with drug-resistant focal epilepsy who achieved seizure control after focal resective surgery. Open-source detectors quantified HFO and spike rates during extraoperative and intraoperative intracranial EEG recordings performed before resection. We determined under which anesthetic conditions HFO and spike rates differentiated the seizure onset zone (SOZ) within the resected area from non-epileptic sites.</p></div><div><h3>Results</h3><p>We analyzed 925 artifact-free electrodes, including 867 at non-epileptic sites and 58 at SOZ sites. Higher Sevoflurane doses significantly increased HFO and spike rates at non-epileptic sites, exhibiting spatial variability among different detectors. These biomarkers were elevated in the SOZ more than in non-epileptic sites under 2–4 vol% Sevoflurane anesthesia, with Cohen’s d effect sizes above 3.0 and Mann-Whitney U-Test r effect sizes above 0.5.</p></div><div><h3>Conclusions</h3><p>We provided normative atlases of HFO and spike rates under different Sevoflurane anesthesia conditions. Sevoflurane elevates HFO and spike rates preferentially in the epileptogenic zone.</p></div><div><h3>Significance</h3><p>Assessing the relative severity of biomarker levels across sites may be relevant for localizing the epileptogenic zone under Sevoflurane anesthesia.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 117-130"},"PeriodicalIF":3.7000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388245724002621","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

We analyzed the dose-dependent effects of Sevoflurane anesthesia on high-frequency oscillations (HFOs) and spike discharges at non-epileptic sites and evaluated their effectiveness in identifying the epileptogenic zone.

Methods

We studied 21 children with drug-resistant focal epilepsy who achieved seizure control after focal resective surgery. Open-source detectors quantified HFO and spike rates during extraoperative and intraoperative intracranial EEG recordings performed before resection. We determined under which anesthetic conditions HFO and spike rates differentiated the seizure onset zone (SOZ) within the resected area from non-epileptic sites.

Results

We analyzed 925 artifact-free electrodes, including 867 at non-epileptic sites and 58 at SOZ sites. Higher Sevoflurane doses significantly increased HFO and spike rates at non-epileptic sites, exhibiting spatial variability among different detectors. These biomarkers were elevated in the SOZ more than in non-epileptic sites under 2–4 vol% Sevoflurane anesthesia, with Cohen’s d effect sizes above 3.0 and Mann-Whitney U-Test r effect sizes above 0.5.

Conclusions

We provided normative atlases of HFO and spike rates under different Sevoflurane anesthesia conditions. Sevoflurane elevates HFO and spike rates preferentially in the epileptogenic zone.

Significance

Assessing the relative severity of biomarker levels across sites may be relevant for localizing the epileptogenic zone under Sevoflurane anesthesia.

查看原文本刊更多论文

七氟醚麻醉下的高频振荡和尖峰率标准图谱

目的我们分析了七氟醚麻醉对非癫痫部位高频振荡（HFOs）和尖峰放电的剂量依赖性影响，并评估了它们在确定致痫区方面的有效性。方法我们研究了21名患有耐药性局灶性癫痫的患儿，他们在接受局灶性切除手术后癫痫得到了控制。在切除手术前进行的术外和术中颅内脑电图记录中，开放源码检测器量化了HFO和尖峰率。我们确定了在何种麻醉条件下，HFO和尖峰率可将切除区域内的癫痫发作起始区（SOZ）与非癫痫部位区分开来。结果我们分析了925个无伪影电极，其中867个位于非癫痫部位，58个位于SOZ部位。较高的七氟烷剂量可显著增加非癫痫部位的 HFO 和尖峰率，不同检测器之间存在空间差异。结论我们提供了不同七氟醚麻醉条件下 HFO 和尖峰率的标准图谱。意义评估不同部位生物标志物水平的相对严重程度可能与定位七氟醚麻醉下的致痫区有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.