Changes in hematopoietic stem cell numbers following acute exercise in non-athlete marathon runners

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2024-09-01 DOI:10.1016/j.advms.2024.09.003

Özgür Günaştı , Çiğdem Özdemir , Kerem T. Özgünen , Gizem Çiftdal , Ertuğrul Gezgin , Selcen Korkmaz Eryılmaz , Ömer Cumhur Boyraz , Abdullah Kılcı , Ümüt Adaş , Bülent Antmen , Sanlı Sadi Kurdak

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引用次数: 0

Abstract

Purpose

Hematopoietic stem cell (HSC) transplant is one of the curative methods for some patients with hematological malignancies. Granulocyte colony-stimulating factor (G-CSF) is the most common drug used to mobilize CD34⁺ cells, generally found in small numbers. Recent evidence showed that exercise causes transient mobilization in HSC. However, the type and intensity of exercise have not been fully revealed. We aimed to detect a significant increase in stem cell levels following 60 min of running at a personalized running pace.

Materials/methods

Eighteen runners, 48.2 ± 1.9 years with peak oxygen consumption of 46.2 ± 1.4 ml/kg/min, were enrolled in the study. The cardiopulmonary exercise test was performed to determine the individual running pace, and the participants ran 60-min on a treadmill at an intensity close to their ventilatory threshold (VT). The blood sampling for HSC count was performed before, immediately after, at the 1st, 4th and 24th hour after the 60-min running.

Results

The CD34⁺ HSCs were 13.9 ± 2.3 cells/μl before and significantly increased immediately after to 19.5 ± 3.6 cells/μl (p < 0.05). The consecutive HSC counts were 15.3 ± 2.2, 19.5 ± 4.8 and 15.1 ± 3.4 cells/μl at the 1st, 4th, and 24th hour, respectively.

Conclusion

The individual data showed that some runners had higher HSC levels than the transplantation limit before and after the 60-min running trail, which was maintained for 24 h. Pre-running high CD34⁺ HSCs may reflect an adaptive response to regular exercise, with a 60-min run near the VT further elevating HSCs. Individualized exercise may be a valuable tool to mobilize the CD34⁺ HSCs in peripheral blood for donors.

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非马拉松运动员急性运动后造血干细胞数量的变化

目的造血干细胞（HSC）移植是治疗某些血液恶性肿瘤患者的方法之一。粒细胞集落刺激因子（G-CSF）是最常用的动员 CD34+ 细胞的药物，但其数量通常较少。最近的证据显示，运动可引起造血干细胞的短暂动员。然而，运动的类型和强度尚未完全揭示。我们的目的是检测以个性化跑步速度跑步60分钟后干细胞水平的显著增加。材料/方法18名跑步者（48.2±1.9岁，峰值耗氧量为46.2±1.4毫升/千克/分钟）参加了研究。进行心肺运动测试以确定个人的跑步速度，参与者在跑步机上以接近其通气阈值（VT）的强度跑步 60 分钟。结果跑步前，CD34+造血干细胞数量为 13.9 ± 2.3 cells/μl，跑步后立即显著增加至 19.5 ± 3.6 cells/μl（p <0.05）。在第1、4和24小时，连续的造血干细胞计数分别为15.3±2.2、19.5±4.8和15.1±3.4个细胞/μl。跑步前的高 CD34+ 造血干细胞水平可能反映了对常规运动的适应性反应，而接近 VT 的 60 分钟跑步则进一步提高了造血干细胞水平。个性化的运动可能是动员外周血中CD34+造血干细胞的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.