Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids1

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-09-13 DOI:10.1016/j.fitote.2024.106212

Emmanuel Gaona-Tovar , Samuel Estrada-Soto , Armando Ramírez-Hernández , Luis Arias-Durán , Hugo Tlahuext , Rafael Villalobos-Molina , Julio C. Almanza-Pérez

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Abstract

Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts. Thus, phytochemical bio-guided fractionation allowed the isolation of angoline (1), dihydrosanguinarine (2), bocconarborine A (3), oxisanguinarine (4), and oxychelerithrine (5) from dichloromethanic and methanolic extracts from the bark of Bocconia arborea (Papaveraceae). The relaxant study on aortic and tracheal rat rings of all benzophenanthridines indicates that 1 was the most active compound of the entire series investigated. Angoline (1) induces its relaxant effect by a concentration-dependent manner through the calcium channel blockade in both tissues.

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Bocconia arborea 及其分离出的苯并菲啶生物碱的血管舒张和气管舒张作用1

Bocconia arborea S. Watson（罂粟科）是墨西哥莫雷洛斯州北部一种丰富的药用植物，可用于治疗多种疾病。本次研究的目的是分离出活性提取物中具有松弛作用的化合物。因此，通过植物化学生物指导分馏法，从 Bocconia arborea（罂粟科）树皮的二氯甲烷和甲醇提取物中分离出了 angoline（1）、dihydrosanguinarine（2）、bocconarborine A（3）、oxisanguinarine（4）和 oxychelerithrine（5）。所有二苯并菲啶类化合物对大鼠主动脉环和气管环的松弛作用研究表明，1 是整个研究系列中活性最强的化合物。安哥啉（1）通过阻断两种组织中的钙通道，以浓度依赖的方式产生松弛作用。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.