Progress in Enzyme-Catalyzed C(sp3)–H Amination

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-09-11 DOI:10.1021/acscatal.4c0494710.1021/acscatal.4c04947

Wei-Nan Xu, Ya-Dong Gao, Ping Su, Luqi Huang, Zhao-Lin He* and Li-Cheng Yang*,

引用次数: 0

Abstract

Amine structures are widely present in various biologically active natural products, drug molecules, and material structures. Among the various strategies of amine synthesis, C(sp³)–H amination has become a powerful strategy due to its atom economy and multiple potential reaction sites compared with conventional amine synthesis methods. Due to the advantages of high catalytic efficiency, high selectivity, environmental friendliness, and high modifiability of the enzyme, the enzymatic C(sp³)–H amination is of great research significance. However, it was not until recent years that natural enzymes capable of catalyzing the amination of C(sp³)–H bonds were discovered. Modifying enzymes to confer unnatural C(sp³)–H amination activity holds great potential. In the past decade, a series of protocols for the amination of C(sp³)–H bonds using engineered enzymes have been developed, several of which showed comparable properties to those of natural enzymes.

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酶催化 C(sp3)-H Amination 的研究进展

胺结构广泛存在于各种具有生物活性的天然产物、药物分子和材料结构中。与传统的胺合成方法相比，C(sp3)-H-胺化以其原子经济性和多个潜在反应位点而成为一种强有力的胺合成策略。由于酶法 C（sp3）-H 氨基化具有催化效率高、选择性强、环境友好、可调控等优点，因此具有重要的研究意义。然而，直到近几年才发现能够催化 C（sp3）-H 键氨基化的天然酶。改造酶使其具有非天然的 C（sp3）-H 氨化活性具有很大的潜力。在过去的十年中，人们开发了一系列利用工程酶胺化 C（sp3）-H 键的方案，其中一些方案显示出与天然酶相当的特性。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.