The role of new inflammatory indices in the prediction of endoscopic and histological activity in inflammatory bowel disease patients.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-12 DOI:10.1097/meg.0000000000002842

Nicola Cesaro,Marco Valvano,Sabrina Monaco,Gianpiero Stefanelli,Stefano Fabiani,Filippo Vernia,Stefano Necozione,Angelo Viscido,Giovanni Latella

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Abstract

BACKGROUND AND AIM Inflammatory indices are promising indicators that can be used to evaluate inflammation in inflammatory bowel diseases (IBDs). The present study aimed to investigate the test accuracy of several inflammatory indices to identify endoscopic, and histological activity in a cohort of IBD patients. STUDY All IBD patients who underwent colonoscopy and blood examination (within 4 weeks and without therapeutic change) were included. For these patients, 10 different inflammatory biomarkers were collected. Our primary outcome was the assessment of accuracy [evaluated with a receiver operating characteristics (ROC) analysis] of each inflammatory biomarker and indices. Furthermore, we tried to establish the optimal cutoff to identify patients with endoscopic and histologic activity among the inflammatory biomarkers and indices with higher performance. RESULTS Regarding endoscopic activity, at the ROC analysis, the systemic inflammation response index (SIRI) showed the best accuracy [area under the curve (AUC), 0.627; confidence interval (CI), 0.552-0.698]. Whereas the ROC analysis showed a suboptimal AUC for the neutrophil-to-lymphocytes ratio (NLR) and platelets-to-lymphocytes ratio; (AUC, 0.620; CI, 0.545-0.691 and AUC, 0.607; CI, 0.532-0.679, respectively). Concerning histological activity, the C-reactive protein albumin ratio (CAR) presented a higher accuracy among the calculated inflammatory biomarkers (AUC, 0.682; CI, 0.569-0.781) while SIRI and NLR presented a subdued diagnostic performance. CONCLUSION SIRI and CAR presented the best test accuracy in an IBD outpatient setting to identify endoscopic and histological activity. However, the test accuracy of all the evaluated Inflammatory indices appeared suboptimal. Fecal calprotectin has still the highest accuracy in predicting endoscopic and histological activity in patients with IBD.

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新的炎症指数在预测炎症性肠病患者的内窥镜和组织学活动中的作用。

背景和目的炎症指数是一种很有前途的指标，可用于评估炎症性肠病（IBD）的炎症情况。本研究旨在探讨几种炎症指标在一组 IBD 患者中识别内镜和组织学活动的测试准确性。研究纳入了所有接受结肠镜检查和血液检查（4 周内且无治疗改变）的 IBD 患者。对这些患者收集了 10 种不同的炎症生物标记物。我们的主要研究结果是评估每种炎症生物标记物和指数的准确性（通过接收器操作特征（ROC）分析进行评估）。结果关于内镜活动，在 ROC 分析中，全身炎症反应指数（SIRI）显示出最佳准确性[曲线下面积（AUC），0.627；置信区间（CI），0.552-0.698]。而 ROC 分析显示，中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值的 AUC 不理想（AUC，0.620；CI，0.545-0.691 和 AUC，0.607；CI，0.532-0.679）。关于组织学活动，在计算出的炎症生物标记物中，C反应蛋白白蛋白比值（CAR）的准确性较高（AUC，0.682；CI，0.569-0.781），而 SIRI 和 NLR 的诊断性能较低。然而，所有被评估的炎症指数的检测准确性似乎都不理想。粪便钙蛋白在预测 IBD 患者的内镜和组织学活动方面的准确性仍然最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464