Ching Kang, Jiaqi Meng, Lan Wang, Chao Chen, Yuxi Chen, Wenwen He, Keke Zhang, Yi Lu, Yanwen Fang, Xiangjia Zhu
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引用次数: 0
Abstract
Background
To investigate the morphologic features of iris in the highly myopic (HM) eyes using a novel swept-source optical coherence tomography (SS-OCT).
Methods
In this retrospective case-control study, 100 eyes of 100 patients scheduled to have cataract surgery were included, categorized into the control (22 mm< AL < 24.5 mm) and HM (AL ≥ 26 mm) groups. Iris volume (IV), area of anterior iris surface (IS), area of posterior IS, and average iris thickness (IT), as well as anterior chamber volume (ACV) and trabecular-iris space at 500 µm (TISA 500) were evaluated using SS-OCT. The associated factors with morphologic features of iris were also investigated.
Results
The HM group showed significantly larger IV and area of anterior and posterior IS than the control group (all P < 0.001), while no difference was identified in IT between the groups. Similar trend in IV was seen in the superior and nasal segments, and area of anterior and posterior IS showed similar trends in all segments except the temporal segment. The IV, area of anterior and posterior IS were all positively correlated with AL (all P < 0.001). Multivariate linear regression revealed that a larger IV was associated with greater ACV. Both larger areas of anterior IS and posterior IS were associated with male, longer AL, greater ACV, and smaller TISA 500.
Conclusions
The HM eyes showed larger IV and area of IS than the control eyes, indicating a coronal expansion of the iris with AL. Iris morphology correlated with anterior chamber angle configuration.
背景使用新型扫源光学相干断层扫描(SS-OCT)研究高度近视(HM)眼虹膜的形态特征。方法在这项回顾性病例对照研究中,纳入了100名计划接受白内障手术的患者的100只眼睛,分为对照组(22 mm<AL<24.5 mm)和HM组(AL ≥ 26 mm)。使用 SS-OCT 评估了虹膜体积(IV)、虹膜前表面积(IS)、虹膜后表面积和平均虹膜厚度(IT),以及前房体积(ACV)和 500 µm 处的小梁-虹膜间隙(TISA 500)。结果 HM 组的 IV 值和前后 IS 的面积明显大于对照组(所有 P 均为 0.001),而 IT 值在两组间无差异。上段和鼻段的 IV 呈类似趋势,除颞段外,所有段的前后 IS 面积呈类似趋势。IV、前部和后部 IS 的面积均与 AL 呈正相关(均为 P < 0.001)。多变量线性回归显示,IV 越大,ACV 越大。结论 与对照眼相比,HM 眼的 IV 和 IS 面积更大,表明虹膜在 AL 的作用下呈冠状扩张。虹膜形态与前房角结构相关。
期刊介绍:
Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists.
Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.