Evaluation of a green synthesized biopolymer polymethyl methacrylate grafted Moringa gum amphiphilic graft copolymer (MOG-g-PMMA) with polymeric-surfactant like properties for biopharmaceutical applications

IF 3.1 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2024-09-19 DOI:10.1007/s00289-024-05504-6

Shreya Sharma, Trishna Bal

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Abstract

The current study utilized a green synthesis where microwave-assisted free radical technique was applied for economical synthesis of a novel biocompatible polymethyl methacrylate grafted moringa gum amphiphilic graft copolymer, focusing on optimization based on percentage yield, percentage grafting, and intrinsic viscosity was performed, and analytical characterizations confirmed successful grafting. The copolymer demonstrated surfactant-like properties, as evidenced by the determined critical micelle concentration (CMC). Evaluation of its impact on poorly water-soluble drugs, simvastatin, and metronidazole benzoate, revealed efficient release within 60 min. Safety assessments, including In vitro assessments like hemocompatibility, bactericidal activity, fish toxicity, and in vivo evaluations such as oral toxicity, and wound repair studies and cell toxicity studies indicated the safety profile of prepared graft copolymer and explored its potential as a biopolymer for pharmaceutical delivery and tissue regrowth platform.

Graphical abstract

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评估一种绿色合成生物聚合物聚甲基丙烯酸甲酯接枝辣木胶两性接枝共聚物（MOG-g-PMMA）在生物制药应用中的聚合表面活性剂特性

本研究采用绿色合成方法，应用微波辅助自由基技术经济地合成了一种新型生物相容性聚甲基丙烯酸甲酯接枝辣木胶两亲接枝共聚物，重点根据产率百分比、接枝百分比和固有粘度进行了优化，分析表征证实接枝成功。通过测定临界胶束浓度（CMC），共聚物显示出类似表面活性剂的特性。对其对水溶性较差的药物辛伐他汀和苯甲酸甲硝唑的影响进行评估后发现，这种共聚物能在 60 分钟内高效释放。安全性评估，包括血液相容性、杀菌活性、鱼类毒性等体外评估，以及口服毒性、伤口修复研究和细胞毒性研究等体内评估，表明了所制备接枝共聚物的安全性，并探索了其作为生物聚合物用于药物输送和组织再生平台的潜力。

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."